中西医结合治疗对帕金森病伴发夜尿症患者夜尿次数、睡眠质量的影响  

Effect of Integrated Chinese and Western Medicine on Nocturia Frequency and Sleep Quality of Parkinson′s Disease Patients with Nocturia

作　　者：蔡扬帆 林凌 饶婷 林坤山 张仁雄 赖靖慧 CAI Yangfan;LIN Ling;RAO Ting;LIN Kunshan;ZHANG Renxiong;LAI Jinghui(Department of Encephalopathy Rehabilitation,Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350003,China)

机构地区：[1]福建中医药大学附属康复医院脑病康复五科,福州350003

出　　处：《世界睡眠医学杂志》2021年第11期1891-1893,共3页World Journal of Sleep Medicine

基　　金：福建中医药大学临床专项(XB2018049)。

摘　　要：目的:探讨穴位贴敷联合托特罗定片对帕金森病(PD)伴发夜尿症患者夜尿次数、睡眠质量的影响。方法:选取2018年11月至2021年3月福建中医药大学附属康复医院PD伴发夜尿症患者50例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组25例。对照组口服酒石酸托特罗定片,观察组实施口服托特罗定片+穴位贴敷干预,总疗程为4周,观察治疗前、治疗后2组患者的平均夜尿次数(PDSS)、睡眠质量(PSQI)的评分变化以及临床疗效。结果:治疗前,2组平均夜尿次数及PDSS、PSQI评分比较差异均无统计学意义(P>0.05);治疗4周后,2组平均夜尿次数及PDSS、PSQI评分均较治疗前改善(P<0.05),与对照组比较,观察组平均夜尿次数、PSQI评分显著低于对照组(P<0.05),PDSS评分显著高于对照组(P<0.05)。结论:穴位贴敷联合托特罗定对减少PD伴发夜尿症患者夜尿频次,改善睡眠质量有积极作用,值得临床应用。Objective:To investigate the effect of acupoint application combined with tolterudine tablets on nocturia frequency and sleep quality of PD patients with nocturia.Methods:A total of 50 patients with nocturia from the Rehabilitation Hospital Affiliated to Fujian University of Chinese Medicine from November 2018 to March 2021 were selected as the study subjects,divided into two groups with 25 cases in each group.The control group received oral tolteridine tartrate tablets,and the observation group received oral tolteridine tartrate tablets plus with point application for a total course of 4 weeks.The average nocturnal frequency(PDSS)and sleep quality(PSQI)scores of the two groups were observed before and 4 weeks after treatment to evaluate the efficacy,and the differences between the two groups were compared.Results:Before treatment,there were no significant differences in average nocturia frequency,PDSS and PSQI scores between 2 groups(P>0.05).After 4 weeks of treatment,the average nocturia times,PDSS and PSQI scores of the two groups were improved compared with those before treatment(P<0.05).Compared with the control group,the average nocturia times and PSQI scores of the observation group were significantly lower than those of the control group(P<0.05),and the PDSS score of the observation group was significantly higher than that of the control group(P<0.05).Conclusion:Acupoint application combined with tolterudine has a positive effect on reducing nocturnal urination frequency and improving sleep quality in PD patients with nocturia,which is worthy of clinical application.

关 键 词：帕金森病 夜尿症 穴位贴敷 睡眠质量 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R244.9[医药卫生—临床医学]