康复新联合庆大霉素对宫颈癌放疗后迟发性放射性直肠炎的临床疗效  

Clinical effects of Kangfuxin combined with gentamicin on delayed radiation proctitis after radiotherapy for cervical cancer

作　　者：李萌 武慧杰 宋冀[1] 轩玉宏[2] LI Meng;WU Huijie;SONG Ji;XUAN Yuhong(Radiotherapy and Chemotherapy Center,Chengde Central Hospital,Chengde 067000,Hebei Province,China;Nursing Department,Chengde Central Hospital,Chengde 067000,Hebei Province,China)

机构地区：[1]河北省承德市中心医院放化疗中心,河北承德067000 [2]河北省承德市中心医院护理部,河北承德067000

出　　处：《世界临床药物》2021年第12期1103-1107,1118,共6页World Clinical Drug

基　　金：承德市科学技术研究与发展计划项目(201701A016)。

摘　　要：目的评价康复新联合庆大霉素对宫颈癌放疗后迟发性放射性直肠炎的临床疗效。方法选择2017年1月至2019年6月河北省承德市中心医院收治的宫颈癌放射治疗后发生迟发性放射性直肠炎的住院患者82例,按随机数字表法分为观察组和对照组,每组41例。观察组使用康复新、生理盐水、庆大霉素共组成的混合液灌肠;对照组应用生理盐水、地塞米松、庆大霉素混合成的灌肠液。对比两组患者治疗前后的直肠镜检黏膜情况、放射性直肠炎病情分级和临床疗效等。结果治疗2周后,两组患者直肠黏膜情况和放射性直肠炎病情分级较治疗前差异均有统计学意义(P<0.05),且观察组疗效优于对照组(P<0.05);观察组总有效率(95.00%)高于对照组(80.00%),差异有统计学意义(P<0.05);患者血清TNF-α、IL-6、CRP水平均明显低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论应用康复新联合庆大霉素治疗迟发性放射性直肠炎具有较好的临床效果,且在治疗直肠黏膜损伤、改善炎症指标方面更具优势。Objective To analyze the clinical efficacy of Kangfuxin combined with gentamicin in the treatment of delayed radiation proctitis after radiotherapy for cervical cancer.Methods The 82 hospitalized patients with delayed radiation proctitis after radiotherapy for cervical cancer treated in our hospital from January 2017 to June 2019 were selected and divided into observation group and control group by random number table method,and there were 41 cases in each group.The observation group used the retention enema method of a mixed solution enema(Kangfuxin+physiological saline+gentamicin).In the control group,normal saline,dexamethasone,and gentamicin were mixed to form an enema solution.Rectal mucosa,grade of radiation proctitis and clinical efficacy were compared between the two groups before and after treatment.Results After two weeks of retention treatment,there were significant differences in the rectal mucosa and the disease grade of radiation proctitis in two groups compared with those before treatment(P<0.05),and the efficacy of observation group was better than control group(P<0.05).The total effective rate of observation group(95.00%)was higher than that of control group(80.00%),and the difference was statistically significant(P<0.05).After two weeks of treatment,the serum levels of TNF-α,IL-6 and CRP in two groups were significantly lower than before treatment,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion The application of Kangfuxin combined with gentamicin in the treatment of delayed radiation proctitis has a good clinical effect,it has more advantages in the treatment of rectal mucosal injury and improvement of inflammatory indicators.

关 键 词：宫颈癌 放疗 放射性直肠炎 保留灌肠 

分 类 号：R737.33[医药卫生—肿瘤] R818.7[医药卫生—临床医学]