E-钙黏蛋白在胃癌中的研究进展及临床应用  

The Research Progress and Clinical Application of E-cadherin in Gastric Cancer

作　　者：赵慧晨 王赛琪 陈贝贝 邢一舒 陈小兵 ZHAO Hui-chen;WANG Sai-qi;CHEN Bei-bei;XING Yi-shu;CHEN Xiao-bing(Affiliated Cancer Hospital of Zhengzhou University,Henan Cancer Hospital,Zhengzhou 450008,China)

机构地区：[1]郑州大学附属肿瘤医院,河南省肿瘤医院,河南郑州450008 [2]河南省肿瘤医院肿瘤内科,河南省郑州市450008

出　　处：《肿瘤学杂志》2021年第10期813-817,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金面上项目(81472714);中原科技创新领军人才项目(204200510023);河省省自然科学基金青年项目(212300410270);河南省科技攻关项目(202102310413);河南省科技攻关——国际科技合作项目(182102410023);河南省医学科技发展攻关计划省部共建项目(SB201901101);河南省医学科技攻关联合共建项目(2018020486);河南省中青年卫生健康科技创新领军人才培养项目(YXKC2020008)。

摘　　要：E-钙黏蛋白(E-cadherin)是一种由CDH1基因编码的跨膜糖蛋白,在维持细胞黏附中起着至关重要的作用。由于E-钙黏蛋白参与调节细胞增殖、侵袭和迁移等信号通路,E-钙黏蛋白缺失可导致胃上皮细胞功能障碍,促进胃癌发生、发展。全文就E-钙黏蛋白在胃癌发生发展中的作用及临床应用价值等内容,总结了E-钙黏蛋白的生物学功能及其在胃癌发生、侵袭、转移和耐药中的调控作用,同时揭示了E-钙黏蛋白在胃癌早期诊断、预后、治疗等方面的应用,以及E-钙黏蛋白激活剂作为抗肿瘤药物的开发现状等,为胃癌的精准治疗提供新思路。Epithelial-cadherin(E-cadherin)is a transmembrane glycoprotein encoded by CDH1,which plays a vital role in maintaining cell-to-cell adhesion.Since E-cadherin participates in the regulation of cell proliferation,invasion,migration and other signaling pathways,the absence of E-cadherin could cause gastric epithelial cell dysfunction and promote the occurrence and development of gastric cancer.In this article,the role of E-cadherin in the occurence and development of gastric cancer and its clinical application were reviewed with summarizing the biological functions of E-cadherin and its regulatory roles in the occurrence,invasion,metastasis and drug resistance of gastric cancer.At the same time,the application of E-cadherin in the early diagnosis,prognosis and therapies of gastric cancer were revealed,as well as the current status of its activators as antitumor drugs,which provide new ideas for precise treatment of gastric cancer.

关 键 词：胃上皮细胞 胃癌早期诊断 精准治疗 胃癌发生 抗肿瘤药物 细胞黏附 功能障碍 细胞增殖 

分 类 号：R735.2[医药卫生—肿瘤]