高迁移率族蛋白B1在肝癌中的研究进展  

Research Progress of High-mobility Group Box 1 Protein in Hepatocellular Carcinoma

作　　者：唐水英 李新民 谢华宁 刘婷[1] 汤晶晶 何晓峰[2] TANG Shui-ying;LI Xin-min;XIE Hua-ning;LIU Ting;TANG Jing-jing;HE Xiao-feng(Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院,广东广州510515 [2]南方医科大学南方医院血管介入科,广东省广州市510515

出　　处：《肿瘤学杂志》2021年第10期860-866,共7页Journal of Chinese Oncology

基　　金：南方医院院长基金(2017B016)。

摘　　要：高迁移率族蛋白B1(HMGB1)是一种高度保守的非组蛋白染色质相关蛋白,与肝细胞肝癌的形成和进展有关。HMGB1参与调控细胞分化、生长、迁移和凋亡的关键信号传导途径的活化,与受体结合,并激活晚期糖基化终产物(RAGE)、丝裂原活化蛋白激酶(MAPK)、toll样受体(TLRs)、核因子-κB(NF-κB)、Src家族激酶信号通路,促进肿瘤细胞的增殖、侵袭和转移等。HMGB1在体内和体外肝癌模型中均能诱导细胞增殖、分化、细胞死亡、血管生成、转移、炎症反应和调节免疫功能,并与肝细胞癌治疗耐药有关。HMGB1及其下游受体RAGE、TLRs、T细胞免疫球蛋白黏蛋白-3(TIM-3)及趋化因子受体4(CXCR4)可能是潜在的抗癌靶点,调控HMGB1的氧化还原状态及靶向特定位置HMGB1可能为肝癌治疗提供新的视角。High-mobility group Box 1 protein(HMGB1)is a highly conserved non-histone chromatin-related protein,which is related to the formation and progression of hepatocellular carcinoma(HCC).HMGB1 is involved in the activation of key signal transduction pathways that regulate cell differentiation,growth,migration and apoptosis,and binds with receptors to activate the receptor of advanced glycation end products(RAGE),mitogen activated protein kinases(MAPK),toll-like receptors(TLRs),nuclear factor kappa B(NF-κB),Src family kinase signaling pathways,thus promoting the proliferation,invasion and metastasis of tumor cells.HMGB1 can induce cell proliferation,differentiation,cell death,angiogenesis,metastasis,inflammatory response and regulate immune function,as well as drug resistance both in vivo and in vitro models of hepatocellular carcinoma.HMGB1 and its downstream receptors RAGE,TLRs,T cell immunoglobulin domain and mucin domain-3(TIM-3)and chemokine receptor 4(CXCR4)might be potential anti-cancer targets,and regulating the redox state of HMGB1 and targeting a specific position of HMGB1 may provide a new perspective for the treatment of liver cancer.

关 键 词：趋化因子受体4 肝癌治疗 高迁移率族蛋白B1 肝癌模型 晚期糖基化终产物 信号传导途径 CXCR4 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]