Role of Autoantibodies in Infertility, Miscarriage, and Assisted Reproductive Technology Outcomes  

作　　者：Hui-Hui Shen Zhen-Zhen Lai Hui-Li Yang Jia-Wei Shi Ming-Qing Li 

机构地区：[1]Laboratory for Reproductive Immunology,Institute of Obstetrics and Gynecology,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200080,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China

出　　处：《Reproductive and Developmental Medicine》2021年第3期161-173,共13页生殖与发育医学（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(NSFC)(Nos.31970798,31671200);the Innovation-oriented Science and Technology Grant from the NPFPC Key Laboratory of Reproduction Regulation(CX2017-2);the Program for Zhuoxue of Fudan University,(JIF157602);the Support Project for Original Personalized Research of Fudan University.

摘　　要：Although considerable advances have been made in the field of assisted reproductive technology(ART),millions of couples still suffer from infertility and miscarriage.In a large number of cases,the etiology of these common reproductive failures remains unknown.However,the significance of autoantibodies in infertility and miscarriage has sparked extensive interest because of their pleiotropic roles in disrupting normal pregnancy.This review discusses the pleiotropic roles of a series of autoantibodies in infertility and miscarriage.A brief recapitulation of how the autoantibodies interfere with ART outcomes and treatments for this type of idiopathic infertility or miscarriage is also provided.While several disputes remain to be resolved,further studies employing better designs and larger sample sizes are required in view of the therapeutic potential of autoantibody inhibitors and the future of contraceptive vaccines.

关 键 词：Antiphospholipid Antibody In Vitro Fertilization OOCYTE SPERM Zona Pellucida 

分 类 号：R711.6[医药卫生—妇产科学] R714.21[医药卫生—临床医学] R714.8