ABCB1 C1236T基因多态性与癫痫耐药的关联性Meta分析  

Association between ABCB1 C1236T polymorphism and antiepileptic drugs resistance:a Meta-analysis

作　　者：陈悦悦 冯钰益 刘勇[2] 陈银楠 李巍 CHEN Yue-yue;FENG Yu-yi;LIU Yong;CHEN Yin-nan;LI Wei(Translational Medicine Research Institute,College of Medicine,Yangzhou University,Jiangsu Yangzhou 225009,China;School of Life and Pharmaceutical Sciences,Dalian University of Technology,Liaoning Dalian 124221,China)

机构地区：[1]扬州大学医学院转化医学研究院,江苏扬州225009 [2]大连理工大学生命科学与药学学院,辽宁大连124221

出　　处：《中国医院药学杂志》2022年第1期35-40,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家重点研发计划(编号:2017YFC1702006);扬州市级计划社会发展项目(编号:YZ2020084)。

摘　　要：目的:研究腺苷三磷酸结合盒转运体B1(ABCB1)基因编码区C1236T多态性与癫痫耐药的联系。方法:在PubMed、Springlink、Web of Science、Cochrane Library和中国知网5个数据库检索有关ABCB1 C1236T多态性与癫痫耐药的病例对照试验。纳入文献的时间为建库至2021年1月。采用RevMan 5.0软件对所纳入的数据进行分析。结果:共纳入24篇文献,癫痫患者中耐药2699例,药物敏感3941例。Meta分析结果显示总人群中,C1236T基因多态性与癫痫耐药之间无显著相关(P>0.05)。种族亚组分析显示,亚洲和印度人群结果和总体人群一致。但高加索人群中,等位基因模型下,ABCB1 C1236T与癫痫耐药具有相关性(OR=1.22,95%CI:1.02~1.47,P=0.03)。而突尼斯人群中,C1236T基因多态性与癫痫耐药在5种基因模型下均具有统计学意义:等位基因模型(OR=0.50,95%CI:0.35~0.72,P=0.0002);共显性基因模型CC/TT(OR=0.28,95%CI:0.13~0.59,P=0.0008);共显性基因模型CT/TT(OR=0.40,95%CI:0.21~0.78,P=0.007);显性模型(OR=0.33,95%CI:0.18~0.62,P=0.0005);隐性模型(OR=0.49,95%CI:0.27~0.88,P=0.02)。结论:ABCB1 C1236T基因多态性与癫痫耐药在总人群,亚洲以及印度人群中未发现相关性,但在高加索和突尼斯人群中可能具有相关性。未来仍需大样本、多中心、高质量的研究进一步证实其相关性。OBJECTIVE To evaluate the association between the polymorphism of ATP-binding cassette subfamily B member 1(ABCB1)C1236 T and drug resistant epilepsy.METHODS Case-control trials related to ABCB1 C1236 T polymorphism and drug resistant epilepsy were retrieved from PubMed,Springlink,Web of Science,Cochrane Library and CNKI.The included literature were collected from the inception to January 2021 of the databases.RevMan 5.0 software was used to analyze the included data.RESULTS A total of 24 studies(2699 patients with drug resistant epilepsy and 3941 patients with drug responsive epilepsy)were included.According to the results of the Meta-analysis in the total population,C1236 T gene polymorphism showed no statistical significance with drug resistant epilepsy(P>0.05).The subgroup based on ethnic showed that the results in the Asian and Indian populations were consistent with the general population.However,in the Caucasian population,association was demonstrated in the allele model(OR=1.22,95%CI:1.02-1.47,P=0.03).In the Tunisian population,the association between C1236 T gene polymorphism and drug resistant epilepsy were statistically significant in such five gene models as allele(OR=0.50,95%CI:0.35-0.72,P=0.0002),co-dominant(CC vs.TT,OR=0.28,95%CI:0.13-0.59,P=0.0008),co-dominant(CT vs.TT,OR=0.40,95%CI:0.21-0.78,P=0.007),dominant(OR=0.33,95%CI:0.18-0.62,P=0.0005)and recessive(OR=0.49,95%CI:0.27-0.88,P=0.02)models.CONCLUSION No association was found between ABCB1 C1236 T gene polymorphism and drug resistant epilepsy in the overall,Asian or Indian populations,while the variant may play a role in drug resistance among the Caucasian and Tunisian populations.Large-sample,multi-center and high-quality researches are still needed to further confirm the correlation.

关 键 词：ABCB1 C1236T 基因多态性 癫痫耐药 META分析 

分 类 号：R742.1[医药卫生—神经病学与精神病学]