子宫动脉栓塞术对子宫肌瘤患者血清IGF-Ⅰ、TSGF及性激素的影响  

Effects of Uterine Artery Embolization on Serum IGF-Ⅰ,TSGF and Sex Hormones in Patients with Uterine Leiomyoma

作　　者：王亮[1] 徐少蓉 曾燕[1] 唐毅[1] WANG Liang;XU Shao-rong;ZENG Yan;TANG Yi(Department of Obstetrics and Gynecology,Central Hospital of Mianyang City,Mianyang,Sichuan 621000,China)

机构地区：[1]绵阳市中心医院妇产科,四川绵阳621000

出　　处：《临床误诊误治》2022年第2期50-53,共4页Clinical Misdiagnosis & Mistherapy

基　　金：四川省医学科研课题项目(S17015)。

摘　　要：目的观察子宫动脉栓塞术(UAE)对子宫肌瘤患者血清胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、肿瘤特异性生长因子(TSGF)及性激素的影响。方法选取2019年1月—2021年1月收治的子宫肌瘤82例,根据治疗方法的不同分为观察组和对照组,每组41例。观察组行UAE治疗,对照组行子宫全切术治疗。术后6个月记录观察组的治疗效果;比较两组术前、术后6个月血清IGF-Ⅰ、TSGF、卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))及静脉血血红蛋白(Hb)水平,并采用生存质量测定量表简表(QOL-BREF)评价生存质量。结果观察组住院时间短于对照组(P<0.01)。观察组治疗总有效率为82.93%。术后6个月,观察组血清FSH、LH、E_(2)水平与术前比较差异无统计学意义(P>0.05),但观察组血清FSH水平低于对照组,LH、E_(2)水平高于对照组(P<0.05)。术后6个月,两组血清IGF-Ⅰ、TSGF水平均较术前降低,Hb水平较术前升高(P<0.05),但两组间比较差异无统计学意义(P>0.05)。术后6个月,两组QOL-BREF评分较术前升高,且观察组高于对照组(P<0.05)。结论UAE对子宫肌瘤患者具有良好的疗效,能在降低血清IGF-Ⅰ、TSGF水平的同时维持性激素的相对稳定,有助于提高患者生活质量。Objective To observe effects of uterine artery embolization(UAE)on serum insulin-like growth factor-Ⅰ(IGF-Ⅰ),tumor-specific growth factor(TSGF)and sex hormones in patients with uterine leiomyoma.Methods A total of 82 patients with uterine leiomyoma admitted between January 2019 and January 2021 were selected and divided into observation group(n=41)and control group(n=41)according to different therapeutic methods.Observation group was treated with UAE,while control group was treated with total hysterectomy.Therapeutic effect of observation group after operation for 6 months was recorded.Levels of serum insulin-like growth factor-Ⅰ(IGF-Ⅰ),TSGF,follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2))and venous blood hemoglobin(Hb)were compared before and after operation operation for 6 months between two groups.The quality of life brief(QOL-BREF)was used to evaluate quality of life.Results The length of hospital stay in observation group was significantly shorter than that in control group(P<0.01).The total effective rate of treatment in observation group was 82.93%.After operation for 6 months,there were no statistically significant differences in serum levels of FSH,LH and E_(2) than those before operation in observation group(P>0.05);compared with those in control group,serum level of FSH was significantly lower,while LH and E_(2) levels were significantly higher in observation group(P<0.05).After operation for 6 months,serum levels of IGF-I and TSGF were significantly reduced,while Hb levels were significantly increased compared with those before operation in two groups(P<0.05),but there were no statistically significant differences in the above indexes between two groups(P>0.05).After operation for 6 months,QOL-BREF scores were significantly increased compared with those before operation in two groups,and the score in observation group was significantly higher than that in control group(P<0.05).Conclusion UAE may achieve good effectiveness in treatment of patients with uterine leiomyom

关 键 词：子宫肌瘤 子宫动脉栓塞术 胰岛素样生长因子-Ⅰ 肿瘤特异性生长因子 雌二醇 黄体生成素 卵泡刺激素 

分 类 号：R737.33[医药卫生—肿瘤]