子宫肌瘤组织中葡萄糖转运蛋白1及硫酸基转移酶1A3表达及其临床意义  

Expression and clinical significance of glucose transporter 1 and sulfate transferase 1A3 in uterine fibroids tissue

作　　者：陆欣怡 闻先萍 丁华峰[1] 倪观太[1] LU Xinyi;WEN Xianping;DING Huafeng;NI Guantai(Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province,241001)

机构地区：[1]皖南医学院附属弋矶山医院,芜湖241001

出　　处：《中国计划生育学杂志》2021年第12期2641-2644,共4页Chinese Journal of Family Planning

基　　金：皖南医学院中青年科研基金,自然科学类(WK2019F26)。

摘　　要：目的:探讨子宫肌瘤组织中葡萄糖转运蛋白1(Glut-1)及硫酸基转移酶1A3(SULT1A3)的表达及其临床意义。方法:采集2019年2月-2021年2月本院收治的行子宫肌瘤剔除术90例(肌瘤组)及子宫脱垂且无其他子宫病变行全子宫切除术78例(对照组)组织标本,采用免疫组织化学检测标本中Glut-1、SULT1A3蛋白表达,分析表达与肌瘤患者临床病理特征关系,采用Kendall相关分析Glut-1与SULT1A3蛋白表达相关性。结果:Glut-1蛋白在肌瘤组织中表达高于正常肌层组织,ULT1A3蛋白表达低于正常肌层组织(均P<0.05)。Glut-1、SULT1A3蛋白在不同年龄、体质指数、肌瘤直径的子宫肌瘤患者肌瘤组织中表达无差异(P>0.05),在FIGO分型2型的子宫肌瘤患者肌瘤组织中均高表达(P<0.01);Glut-1蛋白在非绝经患者肌瘤组织中高表达,SULT1A3蛋白在绝经患者肌瘤组织中高表达,子宫肌瘤组织中Glut-1蛋白与SULT1A3蛋白表达呈负相关(均P<0.01)。结论:较正常肌层组织子宫肌瘤组织中Glut-1蛋白表达升高、SULT1A3蛋白表达降低,且两者表达与患者FIGO分型及绝经状态相关,有望成为子宫肌瘤治疗新靶点之一。Objective:To explore the expression and clinical significance of glucose transporter 1(Glut-1)and sulfate transferase 1A3(SULT1A3)in uterine fibroids tissue.Methods:The uterine fibroids tissue specimens of 90 women after uterine myomectomy(in group A)and the myometrium tissue specimens of 78 women with uterine prolapse and without other uterine lesions after total hysterectomy(in group B)were collected between February 2019 and February 2021.Immunohistochemistry was used to detect the Glut-1 and SULT1A3 protein expressions in tissue samples.The relationship between the levels of Glut-1 protein and SULT1A3 protein of the women with uterine myomectomy and the clinicopathological characteristics of the women was analyzed.Kendall correlation analysis was used to analyze the correlation between the Glut-1 protein level and the SULT1A3 protein level.Results:The expression of Glut-1 protein in uterine fibroids tissues was significantly higher than that in normal myometrium tissues,but the expression of ULT1A3 protein in uterine fibroids tissues was significantly lower than that in normal myometrium tissues(all P<0.05).The Glut-1 and SULT1A3 proteins levels had showed no significant differences in the myometrium tissues among the women with different age,among the women with different body mass index,or among the women with different fibroid diameter(P>0.05).The expressions of Glut-1 protein and ULT1A3 protein in uterine fibroids tissues of the women with FIGO type 2 of uterine fibroids were higher(P<0.01).The expression of Glut-1 protein in uterine fibroids tissues of the women without menopause was high,and the expression of SULT1A3 protein in uterine fibroids tissues of the women with menopause was higher(P<0.05).Correlation analysis showed that the glut-1 protein level in uterine fibroids tissues was negatively correlated with the SULT1A3 protein level in uterine fibroids(P<0.01).Conclusion:The expression level of Glut-1 protein in uterine fibroids tissue is higher than that in normal myometrium tissues,while the exp

关 键 词：子宫肌瘤 葡萄糖转运蛋白1 硫酸基转移酶1A3 临床特征 相关性 

分 类 号：R737.33[医药卫生—肿瘤]