腹腔镜卵巢囊肿切除术前后患者血清CA199、HE4水平及与性激素变化关系  

The levels of serum CA199 and HE4 expressions of the women after laparoscopic ovarian cyst resection and its association with the change of sex hormone

作　　者：伍婷婷 刘萍[1] 唐可[1] 马慧平 WU Tingting;LIU Ping;TANG Ke;MA Huiping(Taihe County People's Hospital, Fuyang, Anhui Province, 236600)

机构地区：[1]安徽省太和县人民医院,236600

出　　处：《中国计划生育学杂志》2021年第10期2112-2116,共5页Chinese Journal of Family Planning

摘　　要：目的:分析卵巢囊肿患者血清糖类抗原199(CA199)、人附睾蛋白4(HE4)水平及其对术后卵巢功能的影响。方法:选取2016年1月—2020年1月本院收治的行腹腔镜卵巢囊肿切除术的106例卵巢囊肿患者作为腹腔镜手术组,常规开腹手术治疗的102例卵巢囊肿患者作为开腹手术组。检测术前、术后24 h时血清CA199、HE4水平,Pearson法分析二者与患者术后血清雌二醇(E_(2))、促黄体生成素(LH)、卵泡刺激素(FSH)水平及疗效关系。结果:腹腔镜手术组术后出血量(38.5±12.2ml)、首次排气时间(17.3±5.0h)、住院时间(6.4±1.3d)均低于开腹手术组,总有效率(95.3%)高于开腹手术组(84.3%)(P<0.05)。两组术后血清CA199、HE4、E_(2)水平、窦准卵泡个数均较术前降低,且腹腔镜手术组低于开腹手术组;两组术后血清LH、FSH水平均较术前升高,且腹腔镜手术组高于开腹手术组(均P<0.05)。腹腔镜手术组血清CA199与HE4水平呈正相关(r=0.322,P=0.001),CA199、HE4均与E_(2)水平呈正相关,与LH、FSH水平呈负相关(P<0.05)。结论:腹腔镜卵巢囊肿切除术患者术后血清CA199、HE4水平降低,与性激素变化密切相关,对术后卵巢功能变化有一定预示作用。Objective:To detect the expression levels of serum carbohydrate antigen 199(CA199)and human epididymal protein 4(HE4)of the women with ovarian cyst,and to analyze the influence of CA199 and HE4 levels on the ovarian function after laparoscopic ovarian cyst resection.Methods:106 women with ovarian cysts who wanted laparoscopic ovarian cyst resection were selected in group A,and 102 women who wanted conventional open ovarian cysts were selected in group B from January 2016 to January 2019.The serum CA199 and HE4 levels of the women in the two groups were detected before and 24 h after surgery.Pearson method was used to analyze the relationship between the CA199 and HE4 levels of the women and their levels of postoperative serum estradiol(E_(2)),luteinizing hormone(LH),and follicle stimulating hormone(FSH),and their efficacy.Results:The postoperative blood loss(38.5±12.2ml),the first exhaust time(17.3±5.0h),and the time of hospital stay(6.4±1.3d)of the women in group A were significant lower than those of the women in group B,but the total effective rate(95.3%)of the women in group A was significant higher than that(84.3%)of the women in group B(P<0.05).The levels of serum CA199,HE4,and E_(2),and the antral follicle count of the women in the two groups had decreased significantly after operation,and which of the women in group A were significant lower than those of the women in group B.The levels of serum LH and FSH of the women in the two groups had increased significantly after operation,and which of the women in were significant higher than those of the women in group B(P<0.05).In group A,the serum CA199 level of the women was positively correlated with their serum HE4 level(r=0.322,P=0.001),and their CA199 level and HE4 level were positively correlated with their E_(2) level,but the CA199 level and HE4 level were negatively correlated with their levels of LH and FSH(P<0.05).Conclusion:The levels of serum CA199 and HE4 of the women have decreased significantly after laparoscopic ovarian cyst resection,which ar

关 键 词：腹腔镜卵巢囊肿切除术 糖类抗原199 人附睾蛋白4 性激素 疗效评估 

分 类 号：R737.31[医药卫生—肿瘤]