不同年龄患者腹腔镜下子宫肌瘤剔除术后卵巢功能恢复差异及血液流变学分析  

Analysis of ovarian function recovery and hemorheology of patients with different age after laparoscopic myomectomy

作　　者：姜慧[1] 房纯[1] JIANG Hui;FANG Chun(Xuanwu Hospital, Capital Medical University, Beijing, 100053)

机构地区：[1]首都医科大学宣武医院,北京100053

出　　处：《中国计划生育学杂志》2021年第11期2301-2304,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨腹腔镜下子宫肌瘤剔除术对不同年龄患者卵巢功能恢复、血液流变学指标、氧化损伤及疼痛情况的影响差异。方法:选取2018年5月-2020年6月在本院妇科行腹腔镜下子宫肌瘤剔除术的患者80例,根据患者年龄分为≤35岁组(n=37)和>35岁组(n=43)。均行腹腔镜下子宫肌瘤剔除术治疗,观察治疗前后两组患者卵巢功能指标、超声血液流变学指标氧化损伤及疼痛指标水平。结果:治疗后,两组患者血清卵泡刺激素、促黄体生成素水平均高于治疗前且≤35岁组低于>35岁组,血清雌二醇水平低于治疗前且≤35岁组高于>35岁组(均P<0.05);两组全血粘度低切、血浆粘度、红细胞聚集指数水平均高于治疗前且≤35岁组低于>35岁组,两组缺血修饰清蛋白、肌红蛋白、三羧酸循环水平均低于治疗前且≤35岁组低于>35岁组,两组心肌细胞P物质、白细胞介素-6、前列腺素E_(2)水平均高于治疗前且≤35岁组低于>35岁组(P<0.05)。结论:腔镜下子宫肌瘤剔除术对不同年龄患者卵巢功能指标、血液流变学指标、氧化损伤指标及疼痛指标有明显影响,且对年龄≤35岁患者的影响相对更小。Objective:To investigate the influence difference of laparoscopic myomectomy for treating patients with different age on their ovarian function recovery,hemorheological parameters,oxidative damage,and pain situation.Methods:80 patients who underwent laparoscopic myomectomy from May 2018 to June 2020 were selected as the research objects.These patients were divided into study group(n=37,≤35 years old)and control group(n=43,>35 years old).Ovarian function indexes,ultrasonic hemorheology indexes,oxidative damage and pain indexes of the patients were observed before and after treatment.Results:After treatment,the levels of serum follicle stimulating hormone and luteinizing hormone of the patients in the two groups had increased significantly,and which of the patients in the study group were significant lower than those of the patients in the control group.The level of serum estradiol of the patients in the two groups had decreased significantly after treatment,and which of the patients in the study group was significant higher than that of the patients in the control group(all P<0.05).The levels of whole blood viscosity,plasma viscosity,and erythrocyte aggregation index of the patients in the two groups had increased significantly after treatment,and which of the patients in the study group were significant lower than those of the patients in the control group.The levels of ischemia-modified albumin,myoglobin,and cyclophosphamide of the patients in the two groups had decreased significantly after treatment,and which of the patients in the study group were significant lower than those of the patients in the control group.The levels of substance P,interleukin-6,and prostaglandin E_(2) of cardiomyocytes of the patients in the two groups had increased significantly after treatment,and which of the patients in the study group were significant lower than those of the patients in the control group(P<0.05).Conclusion:Laparoscopic myomectomy for treating patients with different age has obvious influence on their ovarian fun

关 键 词：腹腔镜下子宫肌瘤剔除术 不同年龄患者 卵巢功能 血液流变学 氧化指标 疼痛 

分 类 号：R73[医药卫生—肿瘤]