CDX2、SOX2在浆液性卵巢癌组织中的表达及其临床意义  

The expressions of caudal type homeobox transcription factor 2 and sex determining region-Y-related high mobility group box 2 in ovarian serous carcinoma tissue and their clinical significance

作　　者：谢双双 张娟[1] 尚丹丹 康燕华[1] XIE Shuangshuang;ZHANG Juan;SHANG Dandan;KANG Yanhua(The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, 075000)

机构地区：[1]河北北方学院附属第一医院,张家口075000

出　　处：《中国计划生育学杂志》2021年第11期2345-2349,2354,2488,共7页Chinese Journal of Family Planning

摘　　要：目的:探究卵巢浆液性肿瘤组织中尾型同源盒转录因子2(CDX2)、Y染色体性别决定区相关的高迁移率族盒蛋白2(SOX2)表达水平及其与预后关系。方法:选取2012年6月-2015年6月本院收治的卵巢浆液性癌患者84例、卵巢交界性浆液性肿瘤患者52例、卵巢良性浆液性肿瘤(卵巢浆液性囊腺瘤)患者63例,收集术中卵巢浆液性癌患者癌组织及癌旁正常组织(距病灶>5 cm),卵巢交界性浆液性肿瘤组织及卵巢良性浆液性肿瘤组织,免疫组织化学染色法检测组织中CDX2、SOX2蛋白表达;Kaplan-Meier生存曲线分析卵巢浆液性癌组织中CDX2、SOX2蛋白表达与患者预后关系;Cox回归模型分析浆液性卵巢癌患者预后影响因素。结果:癌旁正常组织、卵巢良性浆液性肿瘤组织、卵巢交界性浆液性肿瘤组织、卵巢浆液性癌组织中CDX2蛋白高表达率依次降低,SOX2蛋白高表达率依次升高(P<0.05)。与FIGO分期Ⅰ-Ⅱ期、组织学分级G1、无淋巴结转移、无远处转移、未复发患者比较,FIGO分期Ⅲ-Ⅳ期、组织学分级G2-G3、淋巴结转移、远处转移、复发患者癌组织中CDX2蛋白高表达率降低、SOX2蛋白高表达率升高(P<0.05)。卵巢浆液性癌组织中CDX2与SOX2蛋白表达呈负相关(P<0.05)。5年累积生存率,CDX2低表达患者(32.9%)低于高表达患者(71.4%),SOX2低表达患者(68.8%)高于SOX2高表达患者(21.2%)(P<0.05)。Ⅲ-Ⅳ期FIGO分期、淋巴结转移、远处转移及CDX2低表达、SOX2高表达是影响卵巢浆液性癌患者不良预后发生的独立危险因素(P<0.05)。结论:卵巢浆液性癌组织中CDX2蛋白低表达、SOX2蛋白高表达,二者可能在肿瘤进展中存在相互作用,与患者FIGO分期、组织学分级升高及复发、死亡等预后不良发生密切相关。Objective:To investigate the expression levels of caudal type homeobox transcription factor 2(CDX2)and sex determining region-Y-related high mobility group box 2(SOX2)in ovarian serous carcinoma tissue,and to study their relationship with prognosis of patients.Methods:84 patients with ovarian serous carcinoma,52 patients with borderline serous tumor,and 63 patients with benign ovarian serous tumor(ovarian serous cystadenoma)from June 2012 to June 2015 were selected as the research objects.During the operation,the cancer tissues and adjacent normal tissues(more than 5 cm away from the lesion tissue)of patients with ovarian serous carcinoma,the ovarian borderline serous tumor tissues,and benign ovarian serous tumor tissues of the patients were all collected.Immunohistochemical staining was used to detect the protein expression of CDX2 and SOX2.Kaplan-Meier survival curve was used to analyze the relationship between the protein expressions of CDX2 and SOX2 of patients with ovarian serous carcinoma and their prognosis.COX regression model was used to analyze the prognostic factors of patients with serous ovarian cancer.Results:The high expression rate of CDX2 protein in normal tissues,benign ovarian serous tumor tissues,borderline serous tumor tissues,and serous ovarian cancer tissues had decreased in turn,but the high expression rate of SOX2 protein had increased in turn(P<0.05).Compared with those of the patients with FIGO stageⅠ-Ⅱ,with histological grade G1,without lymph node metastasis,without distant metastasis,or without recurrence,the high expression rate of CDX2 protein in carcinoma tissue of the patients with FIGO stageⅢ-Ⅳ,with histological grade G2-G3,with lymph node metastasis,with distant metastasis,or with recurrence of carcinoma had decreased significantly,but the high expression rate of SOX2 protein had increased significantly(P<0.05).The 5-year cumulative survival rate of patients with low expression of CDX2(32.9%)was significant lower than that(71.4%)of patients with high expression of CDX2,a

关 键 词：卵巢浆液性肿瘤 尾型同源盒转录因子2 Y染色体性别决定区相关的高迁移率族盒蛋白2 预后 5年累积生存率 

分 类 号：R73[医药卫生—肿瘤]