双胎妊娠孕妇甲状腺功能及外周血胎儿游离DNA水平分析  

Analysis of detections of thyroid function and fetal free DNA level in peripheral blood of pregnant women with twin pregnancy

作　　者：杨仕英 李绅 于海燕 周宣秀[1] YANG Shiying;LI Shen;YU Haiyan;ZHOU Xuanxiu(Rizhao People's Hospital, Shandong Province, 276800)

机构地区：[1]山东省日照市人民医院,276800

出　　处：《中国计划生育学杂志》2021年第11期2359-2362,共4页Chinese Journal of Family Planning

摘　　要：目的:探究双胎妊娠孕妇甲状腺功能及外周血胎儿游离DNA水平。方法:选取2018年2月-2020年2月本院收治的妊娠期双胎孕妇,其中甲状腺功能异常52例为观察组,功能正常52例为对照组;采用血浆基因组DNA磁珠法抽提孕妇外周血中胎儿游离DNA检测其浓度,酶法检测血糖以及血脂水平,比较两组妊娠期出现高血压、贫血、糖尿病以及胎儿发育不良和早产的发生率。结果:观察组外周血胎儿游离DNA水平,总胆固醇、三酰甘油、低密度脂蛋白胆固醇以及血糖水平均高于对照组(P<0.05);两组高密度脂蛋白胆固醇水平无差异(P>0.05);观察组出现高血压、贫血、糖尿病以及胎儿发育不良等总发生率(26.9%)及早产率(19.2%)均高于对照组(11.5%、1.9%)(P<0.05)。结论:妊娠期双胎孕妇外周血胎儿游离DNA能够反映孕妇甲状腺功能、血糖、血脂水平,甲状腺功能异常的双胎孕妇并发症较多且妊娠结局不理想。Objective:To explore the thyroid function and fetal free DNA level in peripheral blood of pregnant women with twin pregnancy.Methods:The pregnant women with twin pregnancy were selected and were divided 52 women with thyroid dysfunction in observation group and 52 women with normal thyroid function in control group from February 2019 to February 2020.The plasma genomic DNA magnetic bead method was used to extract and detect the fetal free DNA level in the peripheral blood of these women in the two groups.The blood glucose and blood lipid levels of the women in the two groups were detected by enzymic method.The incidences of gestational hypertension,anemia,and diabete of the women during pregnancy,and the fetal dysplasia and premature delivery were compared between the two groups.Results:The levels of fetal free DNA,total cholesterol,triglyceride,low density lipoprotein,cholesterol,and blood glucose of the women in the observation group were significantly higher than those of the women in the control group(P<0.05).There was no significant difference in the low-density lipoprotein level of the women between the two groups(P>0.05).The incidence(26.9%)of total complications,such as hypertension,anemia,diabetes,and fetal dysplasia of the women and the preterm birth rate(19.2%)in the observation group were significantly higher than those(11.5%and 1.9%)in the control group(P<0.05).Conclusion:The level of fetal free DNA in the peripheral blood of the women with twin pregnancy can reflect their thyroid function,blood glucose,and blood lipid levels.The women with twin pregnancy and dysfunction of thyroid function have more complications,and their pregnancy outcomes are not ideal.

关 键 词：双胎妊娠 甲状腺功能 胎儿游离DNA 血糖 血脂 并发症 妊娠结局 

分 类 号：R714.23[医药卫生—妇产科学]