Fas-670 A/G polymorphism predicts prognosis of hepatocellular carcinoma after curative resection in Chinese Han population  

作　　者：Xin-Yi Guo Yi-Lin Xia Zhi-Yang Li Ran Li Yang Fan Wen-Mo Yao Fei Liu 

机构地区：[1]West China School of Medicine,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Liver Surgery&Liver Transplantation Center,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2022年第1期33-40,共8页国际肝胆胰疾病杂志（英文版）

基　　金：supported by grants from the Sichuan Sci-ence and Technology Program(2019YFS0370);National Univer-sity Student Innovation and Entrepreneurship Training Programs(C2019104465).

摘　　要：Background:Apoptosis,also called programmed cell death,is a genetically controlled process against hyperproliferation and malignancy.The Fas-Fas ligand(FasL)system is considered a major pathway for apoptosis in cells and tissues.Thus,this study aimed to investigate whether single nucleotide polymor-phisms(SNPs)in Fas and FasL gene may have effects on the recurrence and survival of patients with hepatocellular carcinoma(HCC)after curative hepatectomy.Methods:We investigated the relationship between Fas rs1800682,rs2234767 and FasL rs763110 poly-morphisms and recurrence-free survival(RFS)as well as overall survival(OS)in 117 Chinese Han patients with HCC who underwent hepatectomy.Results:In Kaplan-Meier survival analysis,only Fas rs1800682(-670 A/G)was associated with RFS and OS.Compared with AA genotype,the AG/GG genotype was significantly associated with better RFS(P=0.008)and OS(P=0.020).Moreover,multivariate Cox regression analysis showed that Fas rs1800682 remained as a significant independent predictor of RFS for HCC patients with hepatectomy[AG/GG vs.AA:adjusted hazard ratio=0.464,95%confidence interval:0.275-0.782,P=0.004],but was not an independent predictor of OS(P=0.395).Conclusions:This study demonstrated that Fas-670 G allele may play a protective role in the recurrence and survival of HCC patients with hepatectomy.Furthermore,Fas rs1800682 polymorphism might be a promising biomarker for HCC patients after hepatectomy.

关 键 词：Hepatocellular carcinoma Single nucleotide polymorphism Cell apoptosis PROGNOSIS RESECTION 

分 类 号：R735.7[医药卫生—肿瘤]