蜡样芽胞杆菌族毒素研究进展  

Advances in Bacillus cereus sensu lato Toxins

作　　者：郑庆芳 王东澍 吕宇飞 王恒樑[1,2] 刘先凯 ZHENG Qing-fang;WANG Dong-shu;LYU Yu-fei;WANG Heng-liang;LIU Xian-kai(Coll.of Food,Shanghai Ocean Uni.,Shanghai 201306;State Key Lab.of Pathogen&Biosec.,Inst.of Bio-Engin.,Milit.Acad.of Sci.,Milit.Acad.of Milit.Med.,Beijing 100071)

机构地区：[1]上海海洋大学食品学院,上海201306 [2]军事科学院军事医学研究院生物工程研究所病原微生物生物安全国家重点实验室,北京100071

出　　处：《微生物学杂志》2021年第6期75-82,共8页Journal of Microbiology

基　　金：艾滋病和病毒性肝炎等重大传染病防治国家科技重大专项(2018ZX10714002);国家自然科学基金项目(81571958,81671979)。

摘　　要：蜡样芽胞杆菌族(Bacillus cereus sensu lato)包括几个具有密切系统发育关系的芽胞杆菌物种,产生的毒素种类繁多,备受人们关注。质粒在菌株中的水平转移,会改变其表型、致病性和毒力,同时也带来分类的问题。通过综述几种蜡样芽胞杆菌毒素的结构特性、作用机制及其危害或生物应用,从质粒水平转移的角度介绍蜡样芽胞杆菌族成员错综复杂的关系。Bacillus cereus sensu lato(BCSL)includes several species having close phylogenetic relationships.They commonly attracted attention because it produces a large variety of toxins.The horizontal plasmid transfer could change their phenotypes,pathogenicity and virulence of the strains,at the same time incurred classification problems.In this article,the structural characteristics,active mechanisms,pathogenicity and bio-applications of some BCSL species,as well their harms of these toxins were reviewed,and the complex relationships among the members of BCSL were introduced from the perspective of horizontal plasmid transfer.

关 键 词：蜡样芽胞杆菌族 炭疽毒素 肠毒素 呕吐毒素 Cry毒素 致病机制 质粒水平转移 

分 类 号：Q93-33[生物学—微生物学]