Estrogen-Induced Uterine Vasodilation in Pregnancy and Preeclampsia  

作　　者：Yan Li Baoshi Han Alejandra Garcia Salmeron Jin Bai Dong-bao Chen 

机构地区：[1]Translational Medical Research Centre,The First Flospital Affiliated to Shandong First Medical University and Shandong Provincial Qianfoshan Hospital,Jinan,Shandong 250014,China [2]Center for Reproductive Medicine,Shandong University,The Key Laboratory of Reproductive Endocrinology of Ministry of Education,National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Jinan,Shandong 250014,China [3]Department of Obstetrics and Gynecology,University of California,Irvine,CA 92697,USA

出　　处：《Maternal-Fetal Medicine》2022年第1期52-60,共9页母胎医学杂志（英文）

基　　金：supported in part by the National Institutes of Health(NIH;grant numbers:R01 ROl HL70562,HD 105699,and R21 HD097498 to Dong-bao Chen).

摘　　要：Normal pregnancy is associated with dramatically increased estrogen biosynthesis whose role is believed to raise uterine blood flow to facilitate the bi-directional maternal-fetal exchanges of gases(O_(2) and CO_(2)),to deliver nutrients,and exhaust wastes to support fetal development and survival.Constrained uterine blood flow in pregnancy is a leading cause of preeclampsia with fetal growth restriction,rendering investigations of uterine hemodynamics to hold a high promise to inform pathways as targets for therapeutic interventions for preeclampsia.The mechanisms of estrogen-induced uterine vasodilation in pregnancy have long been attributed to enhanced endothelium production of nitric oxide,but clinical trials targeting this pathway that dominates uterine hemodynamics have achieved no to little success.Emerging evidence has recently shown a novel proangiogenic vasodilatory role of hydrogen sulfide in regulating uterine hemodynamics in pregnancy and preeclampsia,provoking a new field of perinatal research in searching for alternative pathways for pregnancy disorders especially preeclampsia and intrauterine growth restriction.This minireview is intended to summarize the nitric oxide pathway and to discuss the emerging hydrogen sulfide pathway in modulating estrogen-induced uterine vasodilation in pregnancy and preeclampsia.

关 键 词：ESTROGENS Uterine vasodilation Nitric oxide Hydrogen sulfide PREGNANCY PREECLAMPSIA 

分 类 号：R714.244[医药卫生—妇产科学]