不同影像学征象对手术切除的浸润性黏液腺癌预后影响的Meta分析  

Meta-analysis of the Effect of Different Imaging Signs on the Prognosis of Surgically Resected Invasive Mucinous Adenocarcinoma

作　　者：王绍迪 王文华 冯志军[1] 尚艳 魏静祎 WANG Shao-di;WANG Wen-hua;FENG Zhi-jun;SHANG Yan;WEI Jing-yi(Department of Respiratory and Critical Care Medicine,the First Affiliated Hospital of Henan University,Kaifeng 475000,Henan,China)

机构地区：[1]河南大学第一附属医院呼吸与危重症医学科,河南开封475000

出　　处：《医学信息》2022年第2期114-117,共4页Journal of Medical Information

摘　　要：目的分析不同影像学征象对浸润性黏液腺癌(IMA)无病生存期(DFS)、总生存期(OS)的影响。方法计算机检索PubMed、EMbase、Cochrane和Web of Science数据库,搜集2011年1月1日-2021年1月1日发表的涉及浸润性黏液腺癌预后的病例对照研究,按照纳入标准和排除标准对文献资料进行筛选、提取及质量评价,使用Review Manager 5.3软件进行Meta分析。结果共纳入4项研究,包括451例结节型IMA,87例肺型IMA。Meta分析结果显示:结节型IMA的DFS较肺型IMA更长,差异具有统计学意义(HR=1.80,95%CI:1.19~2.72,P=0.005);结节型IMA与肺型IMA的OS比较,差异无统计学意义(HR=1.77,95%CI:1.11~2.84,P=0.02)。结论相较于结节型IMA,肺型IMA是IMA患者DFS减少的重要危险因素。Objective To analyze the influence of different imaging signs on disease-free survival(DFS)and overall survival(OS)of invasive mucinous adenocarcinoma(IMA).Methods A computer-based search of PubMed,Embase,Cochrane and Web of Science databases was performed to collect case-control studies on the prognosis of invasive mucinous adenocarcinoma published from January 1,2011 to January 1,2021.The literature was screened,extracted and evaluated according to the inclusion criteria and exclusion criteria.Meta-analysis was performed using Review Manager 5.3 software.Results Four studies were included,including 451 cases of nodular IMA and 87 cases of pulmonary IMA.Meta-analysis results showed that the DFS of nodular IMA was longer than that of pulmonary IMA,and the difference was statistically significant(HR=1.80,95%CI:1.19-2.72,P=0.005).There was no significant difference in OS between nodular IMA and pulmonary IMA(HR=1.77,95%CI:1.11-2.84,P=0.02).Conclusion Compared with nodular IMA,pulmonary IMA is an important risk factor for the decrease of DFS in IMA patients.

关 键 词：肺浸润性黏液腺癌 CT分型 无病生存期 总生存期 

分 类 号：R734.2[医药卫生—肿瘤]