八珍汤加减方结合化疗方案序贯治疗气阴两虚型急性淋巴细胞白血病患者的临床疗效分析  

Clinical Effect of Bazhen Decoction Combined with Sequential Treatment of Chemotherapy on Acute Lymphoblastic Leukemia Patients with Deficiency of Qi and Yin

作　　者：牛占恩 井大新 许崇艳[1] NIU Zhan-En;JING Da-Xin;XU Chong-Yan(Department of Hematology,Rizhao Hospital of Yraditional Chinese Medicine,Rizhao 276800,Shandong Province,China)

机构地区：[1]日照市中医医院血液病科,山东日照276800

出　　处：《中国实验血液学杂志》2022年第1期119-125,共7页Journal of Experimental Hematology

摘　　要：目的:研究八珍汤加减方结合化疗方案序贯治疗气阴两虚型急性淋巴细胞白血病患者的临床疗效。方法:选取2014年1月至2016年10月在日照市中医医院收治的气阴两虚型急性淋巴细胞白血病患者84例将患者依据随机对照表法分为研究组和对照组,每组42例。对照组患者均采用标准化疗方案序贯治疗(VDCLP方案+强化化疗),研究组患者在对照组基础上服用八珍汤加减方。比较2组患者治疗1个月后的完全缓解以及随访年3年的死亡情况,检查患者血常规和外周血Th17、Th22、Treg水平以及外周血免疫球蛋白(IgA、IgG和IgM)水平统计分析骨髓抑制以及不良反应的发生情况。结果:研究组患者治疗1个月的完全缓解率(90.48%vs 73.81%)、3年生存率(71.79%vs 47.37%)以及无病生存率(61.54%vs 36.84%)显著高于对照组(P<0.05)。治疗后2组患者粒细胞、WBC、PLT、Hb水平显著增加,且研究组患者血常规各检测值均显著高于对照组(P <0.05)。治疗后研究组患者外周血Th17、Th22水平显著高于对照组,而Treg显著低于对照组(P<0.05)。治疗后研究组患者外周血免疫球蛋白IgA、IgM、IgE水平显著增加且显著高于对照组(P<0.05)。研究组骨髓抑制0级比例显著高于对照组,而Ⅲ级比例显著低于对照组,研究组患者总体抑制程度低于对照组(P <0.05)。研究组患者恶心呕吐、肝肾损伤、感染发生率显著低于对照组(P<0.05)。结论:八珍汤加减方可明显改善气阴两虚型急性淋巴细胞白血病患者化疗方案序贯治疗后的血常规和免疫功能,减轻骨髓抑制,降低不良反应发生率,从而提高临床疗效。Objective:To study the clinical effect of Bazhen decoction combined with sequential treatment of chemotherapy on acute lymphoblastic leukemia patients with deficiency of Qi and Yin.Methods:84 acute lymphoblastic leukemia patients with deficiency of both Qi and Yin treated in the Rizhao Hospital of Traditional Chinese Medicine from January 2014 to October 2016 were selected.According to the method of random control table,the patients were divided into study group and control group,with 42 patients in each group.The patients in the control group was treated by sequentially with standard chemotherapy regimen(VDCLP+intensive chemotherapy),and the patients in the study group were treated by Bazhen decoction based on control group.The complete remission after 1 month of treatment and3-year follow-up mortality were compared between the patients in the two groups,the blood routine,the levels of Th17,Th22,Treg and immunoglobulin(IgA,IgG and IgM) in peripheral blood of the patients were detected,the occurrence of myelosuppression and adverse reactions were analyzed.Results:The complete remission rate(90.48% vs 73.81%)after 1 month of treatment,3-year survival rate(71.79% vs 47.37%) and disease-free survival(61.54% vs 36.84%)of the patients in the study group were significantly higher than those in the control group(P <0.05).After treatment,the levels of granulocytes,WBC,PLT,and Hb of the patients in both of the two groups were increased significantly,and the blood routine test values of the patients in the study group were significantly higher than those in the control group(P <0.05).After treatment,the levels of Th17 and Th22 of the patients in the study group were significantly higher than those in the control group,while Treg was significantly lower than those in the control group(P <0.05).The levels of IgA,IgM and IgE in peripheral blood of the patients in the study group were increased significantly after treatment,and the levels of immunoglobulin of the patients in the study group were significantly higher than those

关 键 词：八珍汤 气阴两虚型 急性淋巴细胞白血病 免疫功能 骨髓抑制 

分 类 号：R733.71[医药卫生—肿瘤] R273[医药卫生—临床医学]