SUVmax和Ki-67在非霍奇金淋巴瘤中的相关性及影响因素研究  

Correlation and Influencing Factors of SUVmax and Ki-67 in Non-Hodgkin Lymphoma

作　　者：李娟 赵铭[2] 原凌[2] 刘洋[2] 马宁 LI Juan;ZHAO Ming;YUAN Ling;LIU Yang;MA Ning(Department of Medical Imaging,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Positron Emission Computed Tomography Center,Shanxi Provincial Cancer Hospital,Taiyuan 030013,Shanxi Province,China)

机构地区：[1]山西医科大学医学影像学系,山西太原030001 [2]山西省肿瘤医院PET-CT中心,山西太原030013

出　　处：《中国实验血液学杂志》2022年第1期136-140,共5页Journal of Experimental Hematology

摘　　要：目的:探讨;F-FDG PET/CT的最大标准摄取值(SUVmax)和核抗原Ki-67在非霍奇金淋巴瘤(NHL)中的影响因素及二者的相关性。方法:回顾性分析185例NHL初诊患者的SUVmax、Ki-67与性别、年龄、最大病灶直径、结外受侵、浅表及深部淋巴结受侵、恶性程度、B症状、临床分期、乳酸脱氢酶、国际预后指数(IPI)评分之间的关系及二者的相关性。结果:185例NHL中,经病理诊断侵袭性B细胞NHL 99例,惰性B细胞NHL 43例,T细胞NHL 43例;侵袭性B细胞NHL的SUVmax与Ki-67均显著高于惰性B细胞NHL及T细胞NHL(P<0.05),而惰性B细胞NHL的SUVmax与Ki-67均显著低于T细胞NHL(P<0.05)。SUVmax和Ki-67与最大病灶直径、结外受侵、恶性程度、乳酸脱氢酶及IPI评分密切相关(P<0.05)。SUVmax与Ki-67表达呈正相关(r=0.615)。通过ROC曲线分析显示SUVmax及Ki-67阳性率能够较准确地反映NHL的侵袭性,其AUC分别为0.871、0.968。结论:SUVmax与Ki-67不受年龄、性别、B症状、分期等影响,是较为客观的定量参数。NHL的SUVmax与Ki-67表达呈正相关,SUVmax及Ki-67对临床诊断NHL的恶性程度有一定的价值。Objective:To investigate the influencing factors of maximum standard uptake value(SUVmax) of;F-fluorodeoxyglucose(;F-FDG) positron emission tomography/computed tomography(PET/CT) and nuclear antigen Ki-67 in non-Hodgkin lymphoma(NHL) and their correlation.Methods:The relationship between SUVmax,Ki-67 and gender,age,maximum lesion diameter,extranodal involvement,superficial and deep lymph node involvement,malignancy,B symptoms,clinical stage,lactate dehydrogenase(LDH) and international prognostic index(IPI) scores and their correlation were reviewed.Results:Among 185 NHL patients,99 cases were aggressive B-cell NHL,43 cases were indolent B-cell NHL,and 43 cases were T-cell NHL,respectively.Obviously,the SUVmax and Ki-67 of aggressive B-cell NHL were higher than those of indolent B-cell NHL and T-cell NHL(P<0.05),while indolent B-cell NHL were lower than those of T-cell NHL(P<0.05).SUVmax and Ki-67 were closely related to maximum lesion diameter,extranodal involvement,malignancy,LDH,and IPI scores(P<0.05).SUVmax was positively correlated with Ki-67 expression(r=0.615).According to the analysis of receiver operating characteristic(ROC),the results showed that the SUVmax and Ki-67 could reflect the aggressiveness of NHL accurately,with an AUC of 0.871 and 0.968.Conclusion:SUVmax and Ki-67 are not affected by age,sex,B symptoms,clinical stage and so on,and are relatively objective quantitative parameters.SUVmax is positively correlated with Ki-67 expression in NHL.SUVmax and Ki-67 have certain value in clinical diagnosis of malignant degree of NHL.

关 键 词：非霍奇金淋巴瘤 正电子发射断层成像/计算机断层扫描 18氟代脱氧葡萄糖 KI-67 

分 类 号：R733.1[医药卫生—肿瘤]