MOCS2 links nucleotide metabolism to nucleoli function  

作　　者：Tamaki Suganuma Selene K.Swanson Madelaine Gogol Timothy J.Garrett Laurence Florens Jerry L.Workman 

机构地区：[1]Workman Lab,Stowers Institute for Medical Research,Kansas City,MO 64110,USA [2]Proteomics,Stowers Institute for Medical Research,Kansas City,MO 64110,USA [3]Computational Biology,Stowers Institute for Medical Research,Kansas City,MO 64110,USA [4]Department of Pathology,Immunology and Laboratory Medicine,University of Florida,College of Medicine,Gainesville,FL 32610,USA

出　　处：《Journal of Molecular Cell Biology》2021年第11期838-840,共3页分子细胞生物学报（英文版）

摘　　要：Dear Editor,Three polyamines,putrescine,spermidine,and spermine,are tightly regulated and are synthesized from arginine,ornithine,and methionine(Miller-Fleming et al.,2015;Figure 1A).Polyamine levels are increased in the red blood cells of amyotrophic lateral sclerosis and Parkinson’s disease(PD)patients(Miller-Fleming et al.,2015).Sulfur amino acid catabolism regulated by the molybdopterin synthase associating complex prevents onset of early events in PD and Alzheimer’s disease(Suganuma et al.,2018).MPT synthase,a heterodimer of MOCS2A and MOCS2B encoded by MOCS2,is essential for the biosynthesis of molybdenum cofactor(Moco).

关 键 词：al. METABOLISM ALZHEIMER 

分 类 号：R764.4[医药卫生—耳鼻咽喉科]