华蟾素联合仑伐替尼治疗经动脉化疗栓塞术后原发性肝癌患者的近期疗效  

Short-term Efficacy Observation of Intravenous Administration of Cinobufalin Combined with Lenvastinib in the Treatment of Primary Liver Cancer Patients After TACE

作　　者：王颖栋 丁海斌 黄子超 朱金祥 郭甲民 WANG Ying-dong;DING Hai-bin;HUANG Zi-chao(Abdominal Tumor Surgery,Shaanxi Cancer Hospital,Xi'an Shaanxi 710061)

机构地区：[1]陕西省肿瘤医院腹部肿瘤外科,陕西西安710061 [2]陕西省肿瘤医院内二科,陕西西安710061

出　　处：《医学临床研究》2022年第1期9-12,共4页Journal of Clinical Research

基　　金：陕西省卫生健康科研基金项目(项目编号:2021D036)。

摘　　要：【目的】探讨华蟾素静脉注射联合仑伐替尼治疗经动脉化疗栓塞(TACE)术后原发性肝癌(PLC)患者的近期疗效。【方法】104例TACE术后PLC患者随机分为观察组和对照组,每组各52例。对照组给予仑伐替尼治疗,观察组在对照组的基础上另给予华蟾素静脉注射治疗,持续治疗4个月后评价疗效并随访12个月。比较两组近期疗效及治疗前后免疫功能、肿瘤标志物变化情况、安全性及生存状况。【结果】观察组临床控制率高于对照组(P<0.05)。治疗后观察组Th1/Th2水平较治疗前提高(P<0.05),Th17/Treg较治疗前降低(P<0.05);对照组治疗后Th1/Th2较治疗前降低(P<0.05),Th17/Tre较治疗前升高(P<0.05);观察组Th1/Th2水平高于对照组(P<0.05),Th17/Treg水平低于对照组(P<0.05)。治疗后,两组癌胚抗原、甲胎蛋白均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。两组不良反应发生率相比较差异均无统计学意义(P>0.05)。对照组12个月存活率为70.59%,低于观察组的80.77%,但两组存活率比较差异无统计学意义(P>0.05)。【结论】华蟾素静脉注射联合仑伐替尼治疗TACE术后PLC可有效提高患者的近期疗效,改善免疫功能,降低肿瘤标志物水平,且耐受性良好。【Objective】To investigate the short-term efficacy of intravenous administration of bufalin combined with lenvastinib in the treatment of primary liver cancer(PLC)after transarterial chemoembolization(TACE).【Methods】A total of 104 patients with PLC after TACE were randomly divided into the observation group and the control group,with 52 cases in each group.The control group was treated with lumphatinib,while the observation group was given intravenous administration of bufalin in addition to the control group.The therapeutic effect was evaluated after 4 months of continuous treatment and followed up for 12 months.The short-term anti-tumor efficacy,the changes of immune function and tumor markers before and after treatment,the safety and survival status of the two groups at 12 months were compared between the two groups.【Results】The clinical control rate of the observation group was higher than that of the control group(P<0.05).After treatment,the levels of Th1/Th2 in the observation group were higher than those before treatment(P<0.05),while the levels of Th17/Treg in the observation group were lower than those before treatment(P<0.05).However,the levels of Th1/Th2 in the control group were lower than those before treatment(P<0.05)and levels of Th17/Treg in the control group were higher than those before treatment(P<0.05).The Th1/Th2 level of the observation group was higher than that in the control group(P<0.05),and Th17/Treg level in the observation group was lower than that in the control group(P<0.05).After treatment,levels of CEA and AFP in both groups were lower than those before treatment(P<0.05),and CEA and AFP levels in the observation group were lower than those in the control group(P<0.05).There was no significant difference in CEA and AFP levels between the two groups before treatment(P>0.05).The safety in the two groups were not significantly different(P>0.05).Also,there was no significant difference in the incidence of various adverse reactions between the two groups(P>0.05).The survival

关 键 词：肝肿瘤/治疗 华蟾蜍毒素/药理学 化学栓塞 治疗性 治疗结果 

分 类 号：R735.7[医药卫生—肿瘤]