脑白质病变与帕金森病患者运动症状及非运动症状的相关性分析  

Correlation analysis of white matter lesions and motor symptoms and non-motor symptoms in Parkinson's patients

作　　者：王伟[1] 曹庆华[1] 孙光玲[1] 苏杭 WANG Wei;CAO Qing-hua;SUN Guang-ling;SU Hang(Brain Center,the Affiliated Hospital of Medical School,NingBo University,NingBo,Zhejiang 315020,China)

机构地区：[1]宁波大学医学院附属医院脑科中心,浙江宁波315020

出　　处：《中华全科医学》2022年第2期237-239,共3页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2020KY875)。

摘　　要：目的探讨脑白质病变(WML)对帕金森病(PD)患者运动症状及非运动症状的影响。方法选择宁波大学医学院附属医院2017年5月-2020年4月原发性PD患者148例并根据是否伴有WML分为WML组83例、非WML组65例,根据Fazekas评分分为WML0级组65例、1级组25例、2级组30例、3级组28例。比较WML组与非WML组一般资料、不同WML分级组PD评分量表Ⅲ(UPDRSⅢ)、PD非运动症状问卷(NMSQ),以logistic回归分析WML与PD患者运动症状、非运动症状的关系。结果WML组UPDRSⅢ评分为(25.52±4.24)分,高于非WML组(18.65±4.12)分(t=9.905,P<0.05),运动障碍程度较非WML组更严重(χ^(2)=50.776,P<0.05)。非WML组NMSQ评分(12.65±1.32)分,WML组NMSQ评分(17.25±3.12)分,WML组NMSQ评分高于非WML组(t=11.126,P<0.05)。多因素回归分析结果显示,UPDRSⅢ评分越高、H&Y分期重度比例越高及NMSQ评分越高均为PD患者WML重度分期的危险因素(P<0.05)。结论WML会增加PD运动症状及非运动症状,且风险程度与WML分级相关。Objective To investigate the effect of white matter lesion(WML)on motor and non-motor symptoms in patients with Parkinson disease(PD).Methods Total 148 patients with primary PD from the Affiliated Hospital of Ningbo University School of Medicine from May 2017 to April 2020 were selected and divided into WML group(83 cases)and non-WML group(65 cases)according to whether they were accompanied by WM.According to Fazekas score,there were 65 cases in WML 0 group,25 cases in grade 1 group,30 cases in grade 2 group and 28 cases in grade 3 group.The general data of WML group and non-WML group,PD score scaleⅢ(UPDRSⅢ)and PD non-motor symptom questionnaire(NMSQ)of different WML grading groups were compared,and the relationship between WML and PD patients with motor symptoms and non-motor symptoms was analyzed by Logistic regression.Results The UPDRSⅢscore of the WML group was(25.52±4.24)points,which was higher than the(18.65±4.12)points of the non-WML group(t=9.905,P<0.05),and the degree of dyskinesia was more serious than that of the non-WML group(χ^(2)=50.776,P<0.05).The NMSQ score of the non-WML group was(12.65±1.32)points,the NMSQ score of the WML group was(17.25±3.12)points,and the NMSQ score of the WML group was higher than that of the non-WML group(t=11.126,P<0.05).The results of multivariate regression analysis showed that the higher the UPDRSⅢscore,the higher the proportion of severe H&Y staging,and the higher the NMSQ score were all risk factors for PD patients with severe WML staging(P<0.05).Conclusion WML can increase PD motor symptoms and non-motor symptoms,and the degree of risk is related to the WML classification.

关 键 词：帕金森病 脑白质病变 运动症状 非运动症状 相关性 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]