原发性肝癌患者行DSA引导下肝动脉化疗栓塞后疗效评估中超声造影的价值  

Value of contrast-enhanced ultrasound in evaluating the efficacy of digital subtraction angiography-guided hepatic artery chemoembolisation in patients with hepatocellular carcinoma

作　　者：范晓华[1] 陈存国[2] 管建民[1] 陆文明[1] 邹涛[1] FAN Xiao-hua;CHEN Cun-guo;GUAN Jian-min;LU Wen-ming;ZOU Tao(Department of Ultrasound,the First People's Hospital of Huzhou,Huzhou,Zhejiang 313000,China;不详)

机构地区：[1]湖州市第一人民医院超声科,浙江湖州313000 [2]浙江省台州医院老年医学科,浙江台州317000

出　　处：《中华全科医学》2022年第2期294-297,共4页Chinese Journal of General Practice

基　　金：浙江省基础公益研究计划项目(LGF19H180001)。

摘　　要：目的探讨超声造影对原发性肝癌(HCC)患者行数字减影血管造影(DSA)引导下肝动脉化疗栓塞(TACE)后疗效评估中的作用。方法选取湖州市第一人民医院和浙江省台州医院2020年1月-2021年4月收治的HCC患者68例为研究对象,均行DSA引导下TACE治疗,治疗前后均采用超声造影进行疗效评估。结果(1)所有患者治疗后始增时间、达峰时间、峰值加速时间显著增加(t=11.701、10.383、10.119,均P<0.05),始增速度、增强速率显著降低(t=9.636、11.318,均P<0.05);(2)有效组治疗后始增时间、达峰时间、峰值加速时间显著大于治疗前(均P<0.05),始增速度、增强速率显著小于治疗前(均P<0.05);治疗后有效组始增时间、达峰时间、峰值加速时间显著大于无效组(t=7.867、12.407、16.127,均P<0.05),始增速度、增强速率显著小于无效组(t=12.134、23.613,均P<0.05);(3)始增时间、达峰时间、峰值加速时间、始增速度及增强速率AUC分别为0.657、0.718、0.642、0.669、0.714。结论超声造影中达峰时间和增强速率预测HCC患者行TACE治疗疗效价值高。Objective To investigate the role of contrast-enhanced ultrasound in evaluating the efficacy of digital subtraction angiography(DSA)-guided hepatic artery chemoembolisation(TACE)in patients with hepatocellular carcinoma(HCC).Methods A total of 68 patients with HCC who were admitted to Huzhou First People's Hospital and Taizhou Hospital of Zhejiang Province from January 2020 to April 2021 were selected as study participants.All patients underwent DSA-guided TACE treatment,and contrast-enhanced ultrasound was used to evaluate the efficacy before and after treatment.Results(1)The initial increase time,peak time and peak acceleration time significantly increased after treatment(t=11.701,10.383,10.119,all P<0.05),whereas the initial growth rate and the enhancement rate significantly reduced(t=9.636,11.318,all P<0.05).(2)The initial increase time,peak time and peak acceleration time were significantly longer after than before treatment(P<0.05)in the effective group(t=7.867,12.407,16.127,all P<0.05).The initial increase rate and enhancement rate were significantly lower after than before treatment(t=12.134,23.613,all P<0.05).(3)The initial increase time,peak time,peak acceleration time,initial increase speed and enhancement rate AUC were 0.657,0.718,0.642,0.669 and 0.714,respectively.Conclusion The peak time and enhancement rate in contrast-enhanced ultrasound have high value in predicting the therapeutic effect of TACE in patients with HCC.

关 键 词：原发性肝癌 肝动脉化疗栓塞 超声造影 数字减影血管造影 疗效 

分 类 号：R735.7[医药卫生—肿瘤] R730.5[医药卫生—临床医学]