p53 codon 72基因多态性与中国女性乳腺癌发生风险关系的系统评价与Meta分析  

Association of p53 codon 72 polymorphism and breast cancer risk in Chinese women:a systematic review and Meta-analysis

作　　者：徐文斌 龚乘丙 李尧 钟广鑫 沈翔 徐斌[1,2] 蒋文龙[1,2] 刘江波 Wen-Bin XU;Cheng-Bing GONG;Yao LI;Guang-Xin ZHONG;Xiang SHEN;Bin XU;Wen-Long JIANG;Jiang-Bo LIU(Department of Thyroid and Breast Ontological Surgery,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan Province,China;Department of Clinical Medicine,Henan University of Science and Technology,Luoyang 471000,Henan Province,China;School of Basic Medical Sciences,Henan University of Science and Technology,Luoyang 471000,Henan Province,China;The First Affiliated Hospital of Xiamen University,Xiamen 361000,Fujian Province,China;Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]河南科技大学第一附属医院甲状腺乳腺肿瘤外科,河南洛阳471000 [2]河南科技大学医学部临床医学院,河南洛阳471000 [3]河南科技大学医学部基础医学院,河南洛阳471000 [4]厦门大学附属第一医院,福建厦门361000 [5]南京大学医学院附属鼓楼医院,南京210008

出　　处：《医学新知》2022年第1期23-32,共10页New Medicine

基　　金：河南省医学科技攻关计划(201504009);河南科技大学2019年度大学生研究训练计划(2019340,2019343)。

摘　　要：目的探讨p53 codon 72基因多态性与中国女性乳腺癌发生风险的关系。方法计算机检索PubMed、Embase、Web of Science、中国知网、万方数据库,收集有关p53 codon 72基因多态性与乳腺癌发生风险的相关研究,检索时限为建库至2021年3月31日。采用Stata 16.0、RevMan 5.4软件进行系统评价和Meta分析。结果共纳入13项研究,包括5411例乳腺癌患者和5758例医院非癌患者或社区健康人群。Meta分析结果显示,纯合子模型[PP vs.RR:OR=1.16,95%CI(0.93,1.46),P=0.200]、隐性模型[PP vs.RR+PR:OR=1.09,95%CI(0.91,1.32),P=0.340]及显性模型[PP+PR vs.RR:OR=1.13,95%CI(0.97,1.30),P=0.120]显示p53 codon 72基因多态性与中国女性乳腺癌发生风险无关,而杂合子模型[PR vs.RR:OR=1.15,95%CI(1.05,1.26),P=0.002]则显示有关。亚组分析进一步发现,样本量较大的研究更易得出p53 codon 72基因多态性与中国女性乳腺癌发生风险相关的结论。此外,在杂合子模型中,对照组为社区健康人群或基因型频率符合Hardy-Weinberg平衡时,也易于得出类似结论。漏斗图和Egger's检验均提示无发表偏倚。敏感性分析显示,除显性模型外,其余模型分析均显示单个研究不改变Meta分析结果。结论杂合子模型分析显示p53 codon 72基因多态性可能与中国女性乳腺癌发生风险有关,未来需纳入更多高质量、大样本研究进行验证。Objective To explore the relationship between p53 codon 72 gene polymorphism and the risk of breast cancer in Chinese women.Methods Relevant literature published in PubMed,Embase,Web of Science,CNKI and WanFang Database was searched systematically from inception to March 31,2021.Two reviewers independently screened the literature,extracted data,and evaluated the risk of bias in the included studies.The systematic review and meta-analysis were performed using Review Manager version 5.4 and Stata version 16.0.Results A total of 13 studies were included in this meta-analysis,including 5,411 breast cancer patients and 5,758 non-tumor or healthy subjects.Total meta-analysis results showed that the homozygous model[PP vs.RR:OR=1.16,95%CI(0.93,1.46),P=0.200],the recessive model[PP vs.RR+PR:OR=1.09,95%CI(0.91,1.32),P=0.340]and the dominant model[PP+PR vs.RR:OR=1.13,95%CI(0.97,1.30),P=0.120]suggested that codon 72 gene polymorphism may not be associated with the risk of breast cancer in Chinese women;but the heterozygous analysis model[PR vs.RR:OR=1.15,95%CI(1.05,1.26),P=0.002]suggests that polymorphism may be associated with the risk of breast cancer in Chinese women.Subgroup analysis further found that studies with larger sample sizes made it easier to conclude that the p53 codon 72 gene polymorphism was related to the risk of breast cancer in Chinese women.In addition,in the heterozygous model,when the control group represented a healthy community or the genotype frequency met the Hardy-Weinberg balance,it was easy to draw similar conclusions that the p53 codon 72 gene polymorphism was related to the risk of breast cancer in Chinese women.Both the funnel plot and Egger's test showed no publication bias.Sensitivity analysis showed that,except for the dominant model,all other model analyses suggested that a single study did not change the results of the meta-analysis.Conclusion Heterozygous model analysis suggests that p53 codon 72 gene polymorphisms may be associated with the risk of breast cancer in Chinese women.In th

关 键 词：P53 基因多态性 乳腺癌 发生风险 META分析 

分 类 号：R737.9[医药卫生—肿瘤]