葶苈大枣泻肺汤合导痰汤联合TP化疗方案治疗痰瘀阻肺型肺癌的临床效果  

Clinical effect of Tingli Dazao Xiefei decoction and Daotan decoction combined with TP chemotherapy regimen in the treatment of lung cancer of phlegm and blood stasis obstructing lung type

作　　者：王凯[1] 赵新汉[2] 刘晓宁 WANG Kai;ZHAO Xinhan;LIU Xiaoning(Integrated TCM&Western Medicine Department(Traditional Chinese Medicine Department),Chang'an District Hospital of the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710100;Medical Oncology Department,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710100,China)

机构地区：[1]西安交通大学第一附属医院长安院区中西医结合科(中医科),陕西西安710100 [2]西安交通大学第一附属医院肿瘤内科,陕西西安710100

出　　处：《临床医学研究与实践》2022年第4期117-120,共4页Clinical Research and Practice

基　　金：西安市卫生健康委员会中医药科研招标课题(No.SZJ201904)。

摘　　要：目的探讨葶苈大枣泻肺汤合导痰汤联合TP化疗方案治疗痰瘀阻肺型肺癌的临床效果。方法选取2019年1月至2021年1月我院收治的200例痰瘀阻肺型肺癌患者,以抽签法将其分为对照组和观察组,各100例。对照组采用TP化疗方案治疗,观察组在对照组基础上联合葶苈大枣泻肺汤合导痰汤治疗。比较两组的临床疗效、肿瘤标志物水平、Foxp3、B7-H3表达水平、免疫功能指标。结果观察组的治疗总有效率为71.00%,高于对照组的45.00%,差异具有统计学意义(P<0.05)。治疗前,两组的CEA、CA125、NSE、CYFRA21-1水平比较,差异无统计学意义(P>0.05);治疗后,两组的CEA、CA125、NSE、CYFRA21-1水平均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的Foxp3、B7-H3表达水平比较,差异无统计学意义(P>0.05);治疗后,两组的Foxp3、B7-H3表达水平均较治疗前降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)比较,差异无统计学意义(P>0.05);治疗后,观察组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组,差异具有统计学意义(P<0.05)。结论葶苈大枣泻肺汤合导痰汤联合TP化疗方案治疗痰瘀阻肺型肺癌的效果显著,可降低肿瘤标志物水平,下调Foxp3、B7-H3表达,改善免疫功能指标,值得临床深入研究。Objective To investigate the clinical effect of Tingli Dazao Xiefei decoction and Daotan decoction combined with TP chemotherapy regimen in the treatment of lung cancer of phlegm and blood stasis obstructing lung type.Methods From January 2019 to January 2021, 200 patients with lung cancer of phlegm and blood stasis obstructing lung type admitted in our hospital were selected and divided into control group and observation group by drawing lots,with 100 cases in each group. The control group was treated with TP chemotherapy regimen, and the observation group was treated with Tingli Dazao Xiefei decoction and Daotan decoction on the basis of the control group. The clinical efficacy, tumor markers levels, Foxp3, B7-H3 expression levels and immune function indexes were compared between the two groups. Results The total effective rate of treatment in the observation group was 71.00%, which was higher than 45.00% in the control group, and the difference was statistically significant( P <0.05). Before treatment, there were no significant differences in the CEA, CA125, NSE and CYFRA21-1 levels between the two groups( P >0.05);after treatment, the CEA, CA125, NSE and CYFRA21-1 levels in the two groups were lower than those before treatment,those in the observation group were lower than the control group, and the differences were statistically significant(P <0.05). Before treatment, there were no significant differences in the Foxp3 and B7-H3 expression levels between the two groups(P>0.05);after treatment, the Foxp3 and B7-H3 expression levels in the two groups were lower than those before treatment, those in the observation group were lower than the control group, and the differences were statistically significant(P<0.05). Before treatment, there were no significant differences in CD3^(+), CD4^(+), CD8^(+)and CD4^(+)/CD8^(+)between the two groups(P >0.05);after treatment, the CD3^(+), CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group, CD8^(+)was lower than that in the control

关 键 词：葶苈大枣泻肺汤 导痰汤 TP化疗方案 痰瘀阻肺型 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]