Drug-induced stuttering:A comprehensive literature review  

作　　者：Naemeh Nikvarz Salehe Sabouri 

机构地区：[1]Department of Clinical Pharmacy,Faculty of Pharmacy,Kerman University of Medical Sciences,Kerman 7616911319,Iran [2]Neuroscience Research Center,Institute of Neuropharmacology,Kerman 7616911319,Iran [3]Department of Pharmaceutical Biotechnology,Kerman University of Medical Sciences,Kerman 7616911319,Iran

出　　处：《World Journal of Psychiatry》2022年第2期236-263,共28页世界精神病学杂志

摘　　要：Drug-induced stuttering(DIS)is a type of neurogenic stuttering(NS).Although DIS has not been reported as frequently as other cases of NS in the literature,it is not a negligible adverse drug reaction(ADR)which can significantly affect the quality of life if not treated.This literature review aims to evaluate the epidemiological and clinical characteristics of DIS and suggests some pathophysiological mechanisms for this ADR.Relevant English-language reports in Google Scholar,PubMed,Web of Science,and Scopus were identified and assessed without time restriction.Finally,a total of 62 reports were included.Twenty-seven drugs caused 86 episodes of stuttering in 82 cases.The most episodes of DIS were related to antipsychotic drugs(57%),mostly including clozapine,followed by central nervous system agents(11.6%)and anticonvulsant drugs(9.3%).The majority of the cases were male and between the ages of 31 and 40 years.Repetitions were the most frequent core manifestations of DIS.In 55.8%of the episodes of DIS,the offending drug was withdrawn to manage stuttering,which resulted in significant improvement or complete relief of stuttering in all cases.Based on the suggested pathophysiological mechanisms for developmental stuttering and neurotransmitters dysfunctions involved in speech dysfluency,it seems that the abnormalities of several neurotransmitters,especially dopamine and glutamate,in different circuits and areas of the brain,including cortico-basal ganglia-thalamocortical loop and white matter fiber tracts,may be engaged in the pathogenesis of DIS.

关 键 词：DRUG Dysfluency Dysphemia PSYCHOTROPICS Speech Stammering 

分 类 号：R969[医药卫生—药理学]