Inflammation-related indicators to distinguish between gastric stromal tumors and leiomyomas:A retrospective study  

作　　者：Yu-Hao Zhai Zhi Zheng Wei Deng Jie Yin Zhi-Gang Bai Xiao-Ye Liu Jun Zhang Zhong-Tao Zhang 

机构地区：[1]Department of General Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China

出　　处：《World Journal of Clinical Cases》2022年第2期458-468,共11页世界临床病例杂志

基　　金：Supported by Beijing Municipal Science&Technology Commission,No.D17100006517003;and Beijing Municipal Administration of Hospitals Incubating Program,No.PX2020001.

摘　　要：BACKGROUND Gastric leiomyomas and gastric stromal tumors are the most common types of gastric tumors encountered.In recent years,the incidence of the two types of tumors has been increasing,but the differential diagnosis is still a challenge in clinical work.However,as there are many reports on stromal tumors and inflammation-related indicators are gradually being paid attention to as important factors in predicting tumor prognosis,the two main purposes of this study were to explore the inflammation-related differences between the two types of tumors and to develop a nomogram as a predictive model.AIM To explore the differences in platelet-lymphocyte ratio(PLR),neutrophillymphocyte ratio(NLR),lymphocyte mononuclear cell ratio(LMR),and SII between the two types of tumors,and simultaneously create the nomogram model.METHODS This study enrolled 88 patients in the gastric stromal tumor group and 56 patients in the gastric leiomyoma group,and the relevant data of the two groups were entered into the system for an integrated analysis.The primary objective of this study was to identify the differences in the inflammation index between the two types of tumors.RESULTS There were statistically significant differences between the two groups in sex,age,and tumor location.In comparison,gastric leiomyomas seem to be more common in women,young patients,and gastric cardia,which is in line with our previous research;the groups showed the following statistical differences:PLR(158.2%vs 134.3%,P=0.028),NLR(2.35 vs 1.68,P=0.000),LMR(5.75 vs 10.8,P=0.004),and SII(546.2 vs 384.3,P=0.003).The results of the multivariate logistic regression analysis showed that sex,age,tumor location,and LMR were independent risk factors for the identification of the two types of tumors.After considering the risk factors selected by the above analysis into the predictive model,a predictive model for distinguishing gastrointestinal stromal tumors from gastric leiomyomas was established as the nomogram.CONCLUSION Gastric leiomyomas and gastric stromal tumo

关 键 词：Gastric leiomyoma Gastrointestinal stromal tumor Platelet-lymphocyte ratio Neutrophil-lymphocyte ratio Lymphocyte mononuclear cell ratio SII Nomogram 

分 类 号：R735.2[医药卫生—肿瘤]