Animal models for SARS-CoV-2 and SARS-CoV-1 pathogenesis,transmission and therapeutic evaluation  

作　　者：Udhaya Bharathy Saravanan Mayurikaa Namachivayam Rajesh Jeewon Jian-Dong Huang Siva Sundara Kumar Durairajan 

机构地区：[1]Department of Microbiology,School of Life Sciences,Central University of Tamil Nadu,Tiruvarur 610005,India [2]Department of Health Sciences,Faculty of Medicine and Health Sciences,University of Mauritius,Reduit 80837,Mauritius [3]CAS Key Laboratory of Quantitative Engineering Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,Guangdong Province,China

出　　处：《World Journal of Virology》2022年第1期40-56,共17页世界病毒学杂志

基　　金：COVID Therapeutics,Department of Biotechnology,Government of India,Ref.No.BT/PR4094/COT/142/20/2021.

摘　　要：There is a critical need to develop animal models to alleviate vaccine and drug development difficulties against zoonotic viral infections.The coronavirus family,which includes severe acute respiratory syndrome coronavirus 1 and severe acute respiratory syndrome coronavirus 2,crossed the species barrier and infected humans,causing a global outbreak in the 21st century.Because humans do not have pre-existing immunity against these viral infections and with ethics governing clinical trials,animal models are therefore being used in clinical studies to facilitate drug discovery and testing efficacy of vaccines.The ideal animal models should reflect the viral replication,clinical signs,and pathological responses observed in humans.Different animal species should be tested to establish an appropriate animal model to study the disease pathology,transmission and evaluation of novel vaccine and drug candidates to treat coronavirus disease 2019.In this context,the present review summarizes the recent progress in developing animal models for these two pathogenic viruses and highlights the utility of these models in studying SARS-associated coronavirus diseases.

关 键 词：Animal models SARS-CoV-1 SARS-CoV-2 COVID-19 Mice HAMSTER Non-human primates PATHOGENESIS TRANSMISSION Therapeutics 

分 类 号：R37[医药卫生—病原生物学]