Asymmetric limb weakness in Guillain-Barre syndrome:Three case reports  

作　　者：Ming Hu Xiang Li Hiu Yi Wong Xun-Gang Feng Yu-Zhong Wang Guo-Rong Zhang 

机构地区：[1]Department of Neurology,The Affiliated Hospital of Jining Medical University,Jining 272000,Shandong Province,China [2]Department of Rehabilitation,The Affiliated Hospital of Jining Medical University,Jining 272000,Shandong Province,China [3]Department of Physiology,Yong Loo Lin School of Medicine,Singapore 536205,Singapore [4]Department of Medical Research Center and Neurology,The Affiliated Hospital of Jining Medical University,Jining 272000,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2022年第6期1896-1902,共7页世界临床病例杂志

基　　金：Supported by Teacher Research Support Foundation of Jining Medical University,No.JYFC2018FKJ140;Natural Science Foundation Youth Project of Shandong Province,No.ZR2020QH110.

摘　　要：BACKGROUND Guillain-Barrésyndrome(GBS)is an autoimmune-mediated peripheral neuropathy characterized by symmetric weakness.Asymmetric weakness in GBS is uncommon and may be easily confused with other differential diagnoses.We herein present three cases of asymmetric GBS and review the literature on this atypical subtype of GBS in order to describe the characteristics of asymmetric GBS and to provide experience for clinicians.CASE SUMMARY Different from patients in the previous reports,our patients showed persistent asymmetric limb weakness from the onset to recovery phase.All three patients were serologically positive for antecedent infections.Two of the three cases had IgG antibodies against ganglioside GM1.Two patients received immunotherapy including intravenous immunoglobulin and plasma exchange,while one patient received only supportive treatment.Autoantibodies against gangliosides,asymmetry of congenital development of blood-nerve barrier and limb use may contribute to the development of asymmetric limb weakness in GBS.CONCLUSION Asymmetric GBS may be a rare clinical variant and should be considered when a patient develops acute and progressive asymmetric limb weakness.The differences in clinical features and prognosis between asymmetric GBS and classic GBS deserve further investigation in a large study.

关 键 词：Guillain-Barrésyndrome Asymmetric limb weakness AUTOANTIBODIES Blood-nerve barrier Case report 

分 类 号：R744.53[医药卫生—神经病学与精神病学]