Primary duodenal dedifferentiated liposarcoma:A case report and literature review  

作　　者：Nah Ihm Kim Ji Shin Lee Chan Choi Jong Hee Nam Yoo Duk Choi Hee Joon Kim Sung Sun Kim 

机构地区：[1]Department of Pathology,Chonnam National University Hospital,Gwangju 61469,South Korea [2]Department of Pathology,Chonnam National University Hwasun Hospital,Hwasun 58128,South Korea [3]Department of Surgery,Chonnam National University Hospital,Gwangju 61469,South Korea

出　　处：《World Journal of Clinical Cases》2022年第6期2007-2014,共8页世界临床病例杂志

基　　金：Supported by Grant from Chonnam National University Hospital Biomedical Research Institute,No.CRI17004-1.

摘　　要：BACKGROUND Dedifferentiated liposarcoma(DDLPS)is an extremely rare neoplasm that exhibits various morphologies.The tumor is characterized by immunoreactivity to MDM2 and CDK4 and can be confirmed by detecting MDM2 amplification via fluorescence in situ hybridization(FISH).Herein,we report an unusual case of DDLPS arising from the duodenum.CASE SUMMARY A 64-year-old man presented with repeated abdominal pain and weight loss.Radiologic studies revealed a mass of the duodenum involving the pancreas.The patient was treated with pylorus-preserving pancreaticoduodenectomy.Histologically,the tumor showed a high-grade sarcoma.Immunohistochemistry demonstrated that the tumor cells were positive for MDM2 and CDK4 expression.MDM2 amplification was detected via FISH,leading to the final diagnosis of DDLPS.Following surgery,the patient was treated in the intensive care unit due to peritonitis,and died 60 d after surgery.CONCLUSION To the best of the authors’knowledge,this is the first case of primary duodenal DDLPS in Korea and the third case in the English-language literature.Care must be taken not to misdiagnose DDLPS as another high-grade tumor.Liposarcoma should be in the differential diagnosis list.

关 键 词：LIPOSARCOMA PRIMARY Small bowel DUODENUM Immunohistochemistry Case report 

分 类 号：R735.31[医药卫生—肿瘤]