Giant nodular fasciitis originating from the humeral periosteum:A case report  

作　　者：Shi-Li Yu Ping-Li Sun Jian Li Meng Jia Hong-Wen Gao 

机构地区：[1]Department of Pathology,The Second Hospital of Jilin University,Changchun 130041,Jilin Province,China

出　　处：《World Journal of Clinical Cases》2022年第5期1572-1579,共8页世界临床病例杂志

基　　金：Supported by Jilin Province Department of Finance Project,No.2019SCZT005,No.2019SRCJ007 and No.2020SCZT007;National Natural Science Foundation of China,No.81902342;and Health Commission of Jilin Province,No.2019Q002.

摘　　要：BACKGROUND Nodular fasciitis(NF)is a self-limiting tumor that mostly occurs in the subcutaneous superficial fascia.NF originating from the appendicular periosteum is extremely rare.A large NF lesion of periosteal origin can be misdiagnosed as a malignant bone tumor and may cause overtreatment.CASE SUMMARY A right axillary mass was found in a 46-year-old man and was initially diagnosed intraoperatively as low-grade sarcoma,but later diagnosed as NF after postresection histopathological evaluation.Furthermore,fluorescence in situ hybridization analysis revealed a USP6 gene rearrangement that confirmed the diagnosis.To the best of our knowledge,this is the first case of NF in the humeral periosteum.CONCLUSION NF poses a diagnostic challenge as it is often mistaken for sarcoma.Postoperative histopathological examination of whole sections can be combined with immunohistochemical staining and,if necessary,the diagnosis can be confirmed by molecular detection,and thus help avoid overtreatment.

关 键 词：Nodular fasciitis PERIOSTEUM Differential diagnosis USP6 Fluorescence in situ hybridization Case report 

分 类 号：R738[医药卫生—肿瘤]