Diffuse invasive signet ring cell carcinoma in total colorectum caused by ulcerative colitis:A case report and review of literature  

作　　者：Zhi Zhang Peng-Fei Yu Guo-Li Gu Yu-Hui Zhang Yu-Ming Wang Zhi-Wei Dong Hai-Rui Yang 

机构地区：[1]Department of General Surgery,Air Force Medical Center,Chinese People's Liberation Army,Beijing 100142,China [2]Graduate School,Hebei North University,Zhangjiakou 075000,Hebei Province,China [3]Health Team,93656 Troop of Chinese People's Liberation Army,Beijing 101113,China

出　　处：《World Journal of Clinical Cases》2022年第5期1729-1737,共9页世界临床病例杂志

基　　金：Supported by Beijing Capital Medical Development Research Fund,No.Shoufa2020-2-5122.

摘　　要：BACKGROUND Diffuse invasive signet ring cell carcinoma of the colorectum is extremely rare clinically.This type of colorectal cancer has certain clinical,pathological and biological characteristics that are different from ordinary colorectal cancer.CASE SUMMARY A 31-year-old young woman was admitted to the hospital for nearly 1 wk due to recurrent symptoms of mucopurulent bloody stools and abdominal distension.Preoperative colonoscopy showed a ring-shaped intestinal wall mass 10 cm from the rectum to the anus.Three pieces of tumor tissue were removed for examination.The pathological results showed rectal mucinous adenocarcinoma.The patient underwent laparoscopic exploration under general anesthesia,and then laparoscopic total colorectal resection,ileal pouch–anal anastomosis and ileostomy were performed.The patient was switched to a FOLFOX+cetuximab regimen.After the fifth cycle,the patient was unable to tolerate further treatment due to tumor progression and multiple organ dysfunction,and died at the end of May 2020.Overall survival was 7 mo.CONCLUSION Carcinogenesis of ulcerative colitis is different from sporadic colon cancer,and the overall prognosis is extremely poor.

关 键 词：Ulcerative colitis Colorectal cancer Signet ring cell carcinoma Case report 

分 类 号：R574.62[医药卫生—消化系统] R735.34[医药卫生—内科学]