Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms:A retrospective study with a large sample size  

作　　者：Yu-Qiong Li Shu-Bo Pan Shu-Shu Yan Zhen-Dong Jin Hao-Jie Huang Li-Qi Sun 

机构地区：[1]Department of Gastroenterology,Changhai Hospital,Shanghai 200433,China [2]Department of Gastroenterology,Suzhou Science and Technology Town Hospital,Suzhou 215000,Jiangsu Province,China [3]Department of Anesthesiology,Changhai Hospital,Shanghai 200433,China [4]Department of Gastroenterology,72^(nd)Group Army Hospital,Huzhou University,Huzhou 313000,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2022年第2期174-184,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Solid pseudopapillary neoplasm of the pancreas(SPN)is a rare neoplasm that mainly affects young women.AIM To evaluate the impact of parenchyma-preserving surgical methods(PPMs,including enucleation and central pancreatectomy)in the treatment of SPN patients.METHODS From 2013 to 2019,patients who underwent pancreatectomy for SPNs were retrospectively reviewed.The baseline characteristics,intraoperative index,pathological outcomes,short-term complications and long-term follow-up data were compared between the PPM group and the conventional method(CM)group.RESULTS In total,166 patients were included in this study.Of them,33 patients(19.9%)underwent PPM.Most of the tumors(104/166,62.7%)were found accidentally.Comparing the parameters between groups,the hospital stay d(12.35 vs 13.5 d,P=0.49),total expense(44213 vs 54084 yuan,P=0.21),operation duration(135 vs 120 min,P=0.71),and intraoperative bleeding volume(200 vs 100 mL,P=0.49)did not differ between groups.Regarding pathological outcomes,tumor size(45 vs 32 mm,P=0.07),Ki67 index(P=0.53),peripheral tissue invasion(11.3%vs 9.1%,P=0.43)and positive margin status(7.5%vs 6%,P=0.28)also did not differ between groups.Moreover,PPM did not increase the risk of severe postoperative pancreatic fistula(3.8%vs 3.0%,P=0.85)or tumor recurrence(3.0%vs 6.0%,P=0.39).However,the number of patients who had exocrine insufficiency during follow-up was significantly lower in the PPM group(21.8%vs 3%,P=0.024).CM was identified as an independent risk factor for pancreatic exocrine insufficiency(odds ratio=8.195,95%confident interval:1.067-62.93).CONCLUSION PPM for SPN appears to be feasible and safe for preserving the exocrine function of the pancreas.

关 键 词：Solid pseudopapillary neoplasm Surgical resection Parenchyma-preserving method Pancreatic exocrine insufficiency 

分 类 号：R735.9[医药卫生—肿瘤]