Central nervous system recurrence in a patient treated for acute promyelocytic leukemia,resulting in sideroblastic anemia:A case report  

作　　者：Haroon Nawaz Ayesha Choudhry William Joseph Morse 

机构地区：[1]Department of Internal Medicine,Westside Regional Medical Center,Plantation,FL 33324,United States [2]MBBS,Fatima Jinnah Medical University,Mozang Chungi,Lahore 54000,Punjab,Pakistan [3]Clinical Medical Student,Ross University School of Medicine,Miramar,FL 33027,United States

出　　处：《World Journal of Hematology》2022年第1期1-5,共5页世界血液学杂志

摘　　要：BACKGROUND Previous cases that have been stated in this article have displayed that around 1%to 7%of patients that have been treated with chemotherapy for acute promyelocytic leukemia developed myelodysplastic syndrome or acute myeloid leukemia.One can see that’s why this case presentation of a 60-year-old man that had a good response to acute promyelocytic leukemia treatment,that later presented with a central nervous system recurrence of acute promyelocytic leukemia and acquired sideroblastic anemia(a form of myelodysplasia)from treatment is a unique case report.CASE SUMMARY The presence of central nervous system relapse in acute promyelocytic leukemia patients is very unlikely compared to recurring mainly in the bone marrow.It is also uncommon to be diagnosed with sideroblastic anemia(form of myelodysplastic syndrome)as a result from treatment for acute promyelocytic leukemia.This case report highlights the detection,treatment/maintenance with idarubicin,all-trans-retinoic-acid,arsenic trioxide,methotrexate,6-mercaptopurine,and ommaya reservoir intrathecal methotrexate administration in a patient that had central nervous system relapse of acute promyelocytic leukemia and acquired sideroblastic anemia.CONCLUSION In essence,first time relapse concerning the central nervous system in treated acute promyelocytic leukemia patients who had a good response to therapy is very uncommon.The acquirement of a myelodysplastic syndrome such as ringed sideroblastic anemia is also rare regarding this patient population.Although such cases are infrequent,this case report represents a unique insight of the detection,treatment,and maintenance of a 60-year-old man diagnosed with acute promyelocytic leukemia,resulting in the acquirement of sideroblastic anemia and central nervous system relapse.

关 键 词：Acute promyelocytic leukemia Central nervous system relapse Sideroblastic anemia All-transretinoic acid MYELODYSPLASIA Case report 

分 类 号：R73[医药卫生—肿瘤]