吡拉西坦联合阿那其根原粉胶囊对轻度认知障碍的改善效果  

Improvement effect of piracetam combined with Anacyclus pyrethrum powder capsule on mild cognitive impairment

作　　者：杨浩[1] 郑军[2] 徐佳骏[3] 陈瑶 张瑞[1] 金小越[1] YANG Hao;ZHENG Jun;XU Jiajun;CHEN Yao;ZHANG Rui;JIN Xiaoyue(Pharmacy Department,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,China;Critical Care Medicine Department,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,China;Neurology Department,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,China)

机构地区：[1]新疆医科大学第六附属医院药学部,新疆乌鲁木齐830002 [2]新疆医科大学第六附属医院重症医学科,新疆乌鲁木齐830002 [3]新疆医科大学第六附属医院神经内科,新疆乌鲁木齐830002

出　　处：《临床医学研究与实践》2022年第5期7-9,共3页Clinical Research and Practice

基　　金：新疆医科大学第六附属医院科研专项基金-自然科学基金(No.LFYKJ2020004)。

摘　　要：目的比较吡拉西坦联合阿那其根原粉胶囊与单用吡拉西坦对轻度认知障碍(MCI)的改善效果。方法选择2016年8月至2018年6月入住我院神经内科的59例MCI患者,按照随机抽签法将其分为对照组(31例,吡拉西坦治疗)和观察组(28例,吡拉西坦联合阿那其根原粉胶囊治疗)。采用蒙特利尔认知评估量表(MoCA)和精神状态检查表(MMSE)评估两组患者治疗前、后的MCI改善情况,并通过门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和肌酐(CREA)水平评估用药安全性。结果治疗前,两组患者的MoCA和MMSE评分比较,差异无统计学意义(P>0.05);治疗后,两组的MoCA和MMSE评分均明显高于治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。治疗前、后,两组的AST、ALT和CREA水平比较,差异均无统计学意义(P>0.05)。结论吡拉西坦联合阿那其根原粉胶囊对MCI的改善效果优于单用吡拉西坦,且安全性较高,值得临床推广应用。Objective To compare the improvement effects of piracetam combined with Anacyclus pyrethrum powder capsule and piracetam alone on mild cognitive impairment(MCI).Methods A total of 59 MCI patients admitted in the neurology department of our hospital from August 2016 to June 2018 were selected and divided into control group(31 cases,treated with piracetam)and observation group(28 cases,treated with piracetam combined with Anacyclus pyrethrum powder capsule)according to random lottery.The improvement of MCI before and after treatment was evaluated by montreal cognitive assessment scale(MoCA)and mental state checklist(MMSE),and the drug safety was evaluated by the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT)and creatinine(CREA).Results Before treatment,there were no significant differences in MoCA and MMSE scores between the two groups(P>0.05);after treatment,the MoCA and MMSE scores of the two groups were significantly higher than those before treatment,and those of the observation group were higher than the control group,the differences were statistically significant(P<0.05).There were no significant differences in AST,ALT and CREA levels between the two groups before and after treatment(P>0.05).Conclusion Piracetam combined with Anacyclus pyrethrum powder capsule is better than piracetam alone in improving MCI,with high safety,which is worthy of clinical application and popularization.

关 键 词：阿那其根 吡拉西坦 轻度认知障碍 

分 类 号：R741.9[医药卫生—神经病学与精神病学]