磷酸川芎嗪注射液联合盐酸倍他司汀对椎基底动脉供血不足患者椎基底动脉血流动力学、凝血功能及氧化应激指标的影响  

Effects of ligustrazine phosphate injection combined with betahistine hydrochloride on vertebrobasilar hemodynamics,coagulation function and oxidative stress indexes in patients with vertebrobasilar insufficiency

作　　者：田慧娟 陈洁 张维 张绒 TIAN Huijuan;CHEN Jie;ZHANG Wei;ZHANG Rong(Xianyang Hospital of Yan'an University,Xianyang 712000,China)

机构地区：[1]延安大学咸阳医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2022年第5期42-45,共4页Clinical Research and Practice

摘　　要：目的探讨磷酸川芎嗪注射液联合盐酸倍他司汀对椎基底动脉供血不足患者椎基底动脉血流动力学、凝血功能及氧化应激指标的影响。方法选取我院2017年10月至2020年10月收治的60例椎基底动脉供血不足患者作为研究对象,以抽签法将其随机分为对照组和观察组,各30例。对照组给予盐酸倍他司汀治疗,观察组在对照组基础上给予磷酸川芎嗪注射液治疗。比较两组患者的治疗效果。结果治疗后,观察组的左侧椎动脉、右侧椎动脉及基底动脉平均血流速度(Vm)均高于对照组(P<0.05)。治疗后,观察组的血浆PT、APTT均长于对照组(P<0.05)。治疗后,观察组的SOD、NO水平高于对照组,MDA水平低于对照组(P<0.05)。治疗后,观察组的ET-1、ICAM-1水平及vWF均低于对照组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论磷酸川芎嗪注射液联合盐酸倍他司汀治疗椎基底动脉供血不足患者的效果显著,可促进患者椎基底动脉血流动力学及凝血功能的改善,减轻机体氧化应激反应,改善血管内皮功能,且安全性高,值得临床推广应用。Objective To explore the effects of ligustrazine phosphate injection combined with betahistine hydrochloride on vertebrobasilar hemodynamics,coagulation function and oxidative stress indexes in patients with vertebrobasilar insufficiency.Methods A total of 60 patients with vertebrobasilar insufficiency treated in our hospital from October 2017 to October 2020 were selected as the research objects.The patients were randomly divided into control group and observation group by drawing lots,with 30 cases in each group.The control group was treated with betahistine hydrochloride,and the observation group was treated with ligustrazine phosphate injection on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the mean blood velocity(Vm)of left vertebral artery,right vertebral artery and basilar artery in the observation group were higher than those in the control group(P<0.05).After treatment,the plasma PT and APTT in the observation group were longer than those in the control group(P<0.05).After treatment,SOD and NO levels in the observation group were higher than those in the control group,while MDA level was lower than that in the control group(P<0.05).After treatment,the ET-1,ICAM-1 levels and vWF in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Ligustrazine phosphate injection combined with betahistine hydrochloride in the treatment of patients with vertebrobasilar insufficiency has a significant effect,it can promote the improvement of vertebrobasilar hemodynamics and coagulation function,reduce the body's oxidative stress response and improve vascular endothelial function,with high safety,which is worthy of clinical promotion and application.

关 键 词：磷酸川芎嗪注射液 盐酸倍他司汀 椎基底动脉供血不足 血流动力学 凝血功能 氧化应激 

分 类 号：R743.32[医药卫生—神经病学与精神病学]