3-硝基苄胺的合成工艺研究  

Synthesis of 3-nitrobenzylamine

作　　者：苏静杰 罗成 周志旭[3] 高婷 游辉 柴慧芳 Su Jingjie;Luo Cheng;Zhou Zhixu;Gao Ting;You Hui;Chai Huifang(School of Pharmaceutical Sciences,Guizhou University of Traditional Chinese Medicine,Guiyang 550025;Shanghai Institute of pharmacy,Chinese Academy of Sciences,Shanghai 201203;School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州中医药大学药学院,贵州贵阳550025 [2]中国科学院上海药物研究所,上海201203 [3]贵州大学药学院,贵州贵阳550025

出　　处：《广东化工》2022年第4期32-34,共3页Guangdong Chemical Industry

基　　金：贵州中医药大学2018年度学术新苗培养及创新探索专项项目培育项目计划(黔科台平台人才[2018]5766号-14);贵州省科技计划项目:黔科合平台人才[2018]5781号。

摘　　要：3-硝基苄胺是一种重要的医药化工中间体,并且3-硝基苄胺在医药及化工合成领域具有重要的作用。本文以3-硝基溴苄为原料,经取代和还原两步反应得到目标化合物。该合成方法具有操作简单、后处理简便且产物纯度和收率较高的优势,产品收率为82.4%,适合工业化生产。此方法为3-硝基苄胺的合成提供了合成路线,也为进一步相关类似的合成研究奠定基础。3-nitrobenzylamine is an important pharmaceutical and chemical intermediate, and 3-nitrobenzylamine plays an important role in the field of medicine and chemical synthesis. In this paper, 3-nitrobenzyl bromide is used as the raw material, and the target compound is obtained through a two-step reaction of substitution and reduction. The synthesis method has the advantages of simple operation, simple post-treatment, and high product purity and yield, and the product yield is 60.6 %, which is suitable for industrial production. This method provides a synthetic route for the synthesis of 3-nitrobenzylamine, and also lays a foundation for further related and similar synthetic research.

关 键 词：3-硝基苄胺 3-硝基溴苄 合成 工艺 中间体 

分 类 号：TQ460.1[化学工程—制药化工]