CK10和CK19在脂溢性角化病和基底细胞癌中的表达和作用  

Expression and Role of CK10 and CK19 in SK and BCC

作　　者：孙业晓 申志华 张艳峰[1] 缪希红[1] 段庆华[1] SUN Yexiao;SHEN Zhihua;ZHANG Yanfeng(Chengde Central Hospital, Hebei Chengde 067000, China)

机构地区：[1]河北省承德市中心医院,河北承德067000

出　　处：《河北医学》2022年第2期305-307,共3页Hebei Medicine

基　　金：河北省承德市科技计划项目,(编号:201903A014)。

摘　　要：目的:通过分析角蛋白CK10,CK19在脂溢性角化病和基底细胞癌中的表达,探讨这两种蛋白在组织细胞增殖分化等方面的差异,根据在不同组织中角蛋白CK10,CK19的表达差异,分析两种疾病的诊断、治疗和预后。方法:用免疫组织化学的方法分别观察40例脂溢性角化病和40例基底细胞癌中CK10和CK19蛋白的表达,通过统计学进行分析。结果:在脂溢性角化中CK10阳性表达远高于基底细胞癌,差异具有统计学意义(P<0.01);在基底细胞癌中CK19阳性表达远高于脂溢性角化病,差异具有统计学意义(P<0.01)。结论:研究进一步证明脂溢性角化病分化良好,为良性病变;而基底细胞癌癌细胞保持未分化,为恶性病变,两者分化差异明显。Objective:To investigate the difference between two proteins in cell proliferation and differentiation by analyzing the expression of Keratin CK10 and CK19 in SK and BCC.And to analyze the diagnosis,treatment and prognosis of the two diseases according to the different expression of CK10 and CK19 in different tissues.Methods:The expression of CK10 and CK19 in 40 cases of SK and 40 cases of BCC were observed by immunohistochemistry,and analyzed statistically.Results:The expression of CK10 in SK was significantly higher than that in BCC(P<0.01).The expression of CK19 in BCC was significantly higher than that in SK(P<0.01).Conclusion:The study further demonstrated that the SK was well differentiated and benign;the basal-cell Carcinoma cells remain undifferentiated and malignant;there are obvious differences.

关 键 词：脂溢性角化病 基底细胞癌 CK10 CK19 

分 类 号：R73[医药卫生—肿瘤]