补体系统对骨偶联作用机制的研究进展  

Research Progress in Mechanisms of Effect of Complements on Bone Coupling

作　　者：李芳瑜 刘晓辉 崔舜[1] Li Fangyu;Liu Xiaohui;Cui Shun(Department of Rheumatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院风湿科,武汉430022

出　　处：《华中科技大学学报（医学版）》2022年第1期120-123,133,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81671560)。

摘　　要：补体系统作为固有免疫的重要组成部分,与骨骼系统有着紧密的联系,在骨骼发育、维持骨重塑平衡以及骨折愈合过程中起着重要的调节作用。骨偶联是成骨细胞介导骨形成与破骨细胞介导骨吸收的精确调节过程,也是骨骼发育、骨重塑、骨折愈合的必要过程。该文综述了补体系统与骨偶联之间相互作用的关系,以揭示补体系统对骨偶联的影响及作用机制,为骨代谢相关疾病的治疗提供新思路。As an important component of innate immunity, complement system is closely related to skeletal system, which plays an important regulatory role in bone development, maintenance of bone-remodeling homeostasis and fracture healing.Bone coupling is a precise regulatory process of osteoblast-mediated bone formation and osteoclast-mediated bone resorption, and is also an essential process of bone development, bone remodeling and fracture healing.This review summarizes the interaction between complement system and bone coupling, and reveals the effects and possible mechanism of complement system on bone coupling for the purpose to provide new ideas for the treatment of bone metabolism related diseases.

关 键 词：补体 骨偶联 骨重塑 成骨细胞 破骨细胞 

分 类 号：R681[医药卫生—骨科学]