巨磁阻抗传感器在生物检测领域的研究进展  

Research Progress of Giant Magneto-Impedance Sensors in Biological Detection Field

作　　者：孔云 吴次南 魏千惠 张青竹[3] 魏峰 Kong Yun;Wu Cinan;Wei Qianhui;Zhang Qingzhu;Wei Feng(College of Big Data and Information Engineering,Guizhou University,Guiyang 550025,China;State Key Laboratory of Smart Sensing and Advanced Materials,GRIMAT Engineering Institute Co.,Ltd.,Beijing 101407,China;Integrated Circuit Advanced Process R&D Center,Institute of Microelectronics,Chinese Academy of Sciences,Beijing 100029,China;Technology Development Division,GRINM Group Co.,Ltd.,Beijing 100088,China)

机构地区：[1]贵州大学大数据与信息工程学院,贵阳550025 [2]有研工程技术研究院智能传感功能材料国家重点实验室,北京101407 [3]中国科学院微电子研究所集成电路先导工艺中心,北京100029 [4]有研科技集团科技发展部,北京100088

出　　处：《微纳电子技术》2022年第1期1-8,30,共9页Micronanoelectronic Technology

基　　金：有研集团科技创新基金资助项目(2020DY0102)。

摘　　要：对巨磁阻抗(GMI)效应的产生以及基于GMI效应制备的生物传感器的优势进行了简单阐述,分析了GMI生物传感器应用于生物检测的工作原理,并对GMI生物传感器的制备方法以及主要的薄膜结构对GMI比值的影响进行了综合介绍,总结了GMI生物传感器在生物检测中的应用,并重点阐述了GMI生物传感器在免疫磁珠、肿瘤标志物、细菌、病毒、细胞检测以及血栓模拟检测方面的研究进展。最后,对当前GMI生物传感器的检测应用所面临的困难进行了总结,并对GMI生物传感器未来的发展方向进行了展望。The production of the giant magneto-impedance(GMI)effect and the advantages of biosensors prepared based on the GMI effect are briefly explained,and the working principle of GMI biosensors used in biological detection is analyzed.The preparation methods of GMI biosensors and the influence of main film structures on GMI ratio are comprehensively introduced.The application of GMI biosensors in biological detection is summarized.The research progress of GMI biosensors in the detection of immunomagnetic beads,tumor markers,bacteria,virus,cells and thrombus simulation detection are emphasized.Finally,the difficulties faced in the current GMI biosensor detection applications are summarized,and the future development direction of GMI biosensors is prospected.

关 键 词：巨磁阻抗(GMI) 生物传感器 生物检测 免疫磁珠 巨磁阻抗(GMI)比值 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]