Functional in vivo assessment of stem cell-secreted pro-oligodendroglial factors  

作　　者：Jessica Schira-Heinen Iria Samper Agrelo Veronica Estrada Patrick Küry 

机构地区：[1]Department of Neurology,Neuroregeneration Laboratory,Medical Faculty,Heinrich-Heine-University,Düsseldorf,Germany

出　　处：《Neural Regeneration Research》2022年第10期2194-2196,共3页中国神经再生研究（英文版）

基　　金：supported by the Christiane and Claudia Hempel Foundation for clinical stem cell research,iBrain,Stifterverband/Novartisstiftung and the James and Elisabeth Cloppenburg,Peek and Cloppenburg Düsseldorf Stiftung(to PK).

摘　　要：The role of adult neural stem cells(NSCs)in demyelinating diseases of the central nervous system(CNS):Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS.Originating from radial glial cells during nervous system development,adult NSCs are localized in the subgranular zone of the hippocampus and the subventricular zone(SVZ)of the lateral brain ventricles,the main neurogenic zones of the adult brain.Hippocampal precursor cells(type 1 cells)exhibiting properties of radial glial cells give rise to granule neurons through distinct intermediate precursor cells,and integrate into the hippocampal circuitry[reviewed by Kempermann et al.(2015)].Likewise,under physiological conditions,neuron generation by mouse SVZ-derived NSCs(also known as type B cells)is the predominant cell fate,which thereby results in large numbers of transient amplifying precursor cells(also known as type C cells)which in turn differentiate into neuroblasts(type A cells).These cells migrate along the rostral migratory stream into the olfactory bulb where they undergo maturation into local interneurons.The structure of the rodent SVZ differs from that of the human SVZ since the proliferative capacity is reduced,and migration of neuroblasts is a rare event in adult humans[reviewed by Lim and Alvarez-Buylla(2016)].

关 键 词：thereby MIGRATE predominant 

分 类 号：R741[医药卫生—神经病学与精神病学]