膜进样质谱技术及其应用  

Membrane Inlet Mass Spectrometry Techniques and Their Applications

作　　者：王卫国 黄卫[2] 阮慧文[2] 徐楚婷 杨俊超 李斌 李海洋[2] WANG Wei-guo;HUANG Wei;RUAN Hui-wen;XU Chu-ting;YANG Jun-chao;LI Bin;LI Hai-yang(State Key Laboratory of NBC Protection for Civilian,Beijing 102205,China;Dalian Key Laboratory for Online Analytical Instrumentation,Key Laboratory of Separation Science for Analytical Chemistry,Chinese Academy of Sciences,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;Yunnan Police College,Kunming 650223,China)

机构地区：[1]国民核生化国家重点实验室,北京102205 [2]中国科学院大连化学物理研究所,中国科学院分离分析化学重点实验室,大连市在线谱学分析仪器重点实验室,辽宁大连116023 [3]云南警官学院,云南昆明650223

出　　处：《分析测试学报》2022年第2期283-289,共7页Journal of Instrumental Analysis

基　　金：国家自然科学基金委重大研发计划(91961124);国民核生化灾害防护国家重点实验室开放课题(sklnbc2018-14);云南省刑事科学技术重点实验室开放课题(YJXK119001);中国科学院大连化学物理研究所所创基金(DICPI201951,DICP ZZBS201701)。

摘　　要：膜进样质谱(MIMS)具有简单、快速和高灵敏等优点,在现场检测中的应用日益广泛。该技术利用半透膜将目标化合物从复杂的气相、液相体系中选择性分离后进入质谱进行分析检测。由于其可在不经色谱分离和样品前处理条件下实现复杂实际样品的分析,特别适合于现场应用。该文综述了膜进样质谱的原理和主要组成,重点论述了膜进样-单光子软电离质谱方面的技术进展以及膜进样质谱在环境、生态学、生命科学、生物等领域的应用进展。最后,对膜进样质谱今后的发展趋势进行了总结和展望。Membrane inlet mass spectrometry(MIMS)utilizes a semi-permeable membrane to selectively transfer the target molecules in gas,liquid or solid mixtures into a mass spectrometer,yielding on line monitoring volatile organic compounds. It has been widely used for the continuous monitoring on line without chromatographic separation and sample pretreatment,where the inferences from the bulk of the sample matrix could be avoided.In this review,the principle and structure of MIMS instrument were introduced,including the membrane materials,ionization sources,the mass spectrometers and also interface configurations. The progresses of MIMS instruments in the laboratory were presented,especially on the combination of membrane with the single photon ionization time of flight mass spectrometry.A new membrane inlet with buffer cell for time of flight mass spectrometry was developed to increase the limit of detection.Then,the combination of helical hollow fiber membrane inlet with time of flight mass spectrometry and ion mobility spectrometry was introduced for detection trace volatile organic compounds in air and water.Moreover,the in-source stretched hollow fiber membrane inlet and in-source helical hollow fiber membrane interface were also developed for higher limit of detection and faster responding time.Recently,MIMS has been widely used in a lot of field including environmental pollutions monitoring,also the field of ecology,life sciences,microbial metabolism.In the field of environment,some methods based on MIMS were developed to measure the chlorinated and brominated-amines,aromatic pollutants in drinking water.MIMS also was used for direct analysis of the naphthenic acids in constructed wetland samples and polyaromatic hydrocarbons in soil and aqueous samples.In the field of ecology,MIMS was used to investigate the abundance and concentration of aqueous nitrate,nitrite and ammonium.It also used to measure the denitrification,anammox,DNRA rates,and net N2 flux in paddy soil.In the field of life sciences,membrane inlet ion

关 键 词：膜进样 质谱 电离源 应用 

分 类 号：O657.63[理学—分析化学] G353.11[理学—化学]