非小细胞肺癌中程序性死亡受体-1、程序性死亡 配体-1和血管内皮生长因子的表达及临床病理意义  

Expression and clinicopathological significance of programmed death receptor-1,programmed death ligand-1 and vascular endothelial growth factor in non-small cell lung cancer

作　　者：秦珍珠[1] 梁运霞[1] 王丹[1] 张玉文[1] QIN Zhen-zhu;LIANG Yun-xia;WANG Dan;ZHANG Yu-wen(Department of Pathology,First People's Hospital of Shangqiu City,Shangqiu,Henan 476100,China)

机构地区：[1]商丘市第一人民医院病理科,河南商丘476100

出　　处：《中国卫生检验杂志》2022年第2期226-229,233,共5页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者程序性死亡受体-1(PD-1)、程序性死亡配体-1(PD-L1)和血管内皮生长因子(VEGF)蛋白表达与临床病理资料相关性。方法选取本院120例NSCLC患者为肺癌组,105例肺部良性疾病患者为良性病变组。观察2组患者PD-1、PD-L1和VEGF蛋白表达水平,并随访生存情况。结果肺癌组患者PD-1、PD-L1和VEGF蛋白阳性率均高于良性病变组(P<0.01);PD-1蛋白在男性、有吸烟史、腺癌和驱动基因阳性患者高表达(P<0.05),PD-L1蛋白在男性、年龄<60岁、有吸烟史和腺癌患者中高表达(P<0.05),VEGF蛋白在非腺癌和(Ⅲ+Ⅳ)期患者中高表达(P<0.05);肺癌组上述蛋白阳性患者中位PFS和中位OS均短于阴性患者(P<0.05)。结论NSCLC患者PD-1、PD-L1和VEGF蛋白阳性率高于肺部良性病变患者,其表达水平与部分临床病理资料相关,且PD-1、PD-L1和VEGF蛋白阳性表达者生存期较短。Objective To explore the correlation between the protein expression of programmed death receptor-1(PD-1),programmed death ligand-1(PD-L1)and vascular endothelial growth factor(VEGF)in patients with non-small cell lung cancer(NSCLC)and clinicopathological data.Methods A total of 120 NSCLC patients in our hospital were selected as lung cancer group,105 patients with benign lung disease were selected as benign lesions group.The protein levels of PD-1,PD-L1 and VEGF in the two groups were observed,and the survival was followed up.Results The positive rates of PD-1,PD-L1 and VEGF proteins in the lung cancer group were higher than those in the benign lesion group(P<0.01);PD-1 protein was highly expressed in male patients with smoking history,adenocarcinoma and driver gene positive patients(P<0.05),the PD-L1 protein was highly expressed in male patients aged<60 years with smoking history and adenocarcinoma(P<0.05),and the VEGF protein was highly expressed in non-adenocarcinoma and(Ⅲ+Ⅳ)stage patients(P<0.05).In lung cancer group,the median PFS and median OS were shorter than those in negative patients(P<0.05).Conclusion The positive rates of PD-1,PD-L1 and VEGF protein in NSCLC patients are higher than that in patients with benign lung lesions,and its level is related to some clinicopathological data,and the survival time of patients with positive PD-1,PD-L1 and VEGF protein is shorter.

关 键 词：非小细胞肺癌 程序性死亡受体-1 程序性死亡配体-1 临床病理 预后 

分 类 号：R734.2[医药卫生—肿瘤]