白细胞介素1和白细胞介素17基因多态性与胃癌易感性的相关研究  

Study on relationship between polymorphisms of IL-1 and IL-17 and gastric cancer

作　　者：李霞[1] 张恩[1] 谢服役[1] 章丽巧 孙汶汶 LI Xia;ZHANG En;XIE FU-yi;ZHANG Li-qiao;SUN Wen-wen(Clinical Laboratory,Ningbo Medical Center Lihuili Hospital,Ningbo,Zhejiang 315040,China)

机构地区：[1]宁波市医疗中心李惠利医院检验科,浙江宁波315040

出　　处：《中国卫生检验杂志》2022年第1期76-78,82,共4页Chinese Journal of Health Laboratory Technology

基　　金：宁波市医学科技计划项目(2018A57)。

摘　　要：目的研究IL-1和IL-17基因多态性与胃癌的相关性。方法以病例-对照的方法收集宁波市医疗中心李惠利医院150例胃癌患者(疾病组)及150例对照组;采用SNaPshot PCR对疾病组和对照组的IL-1RN rs9005与IL-17A rs2275913基因多态性进行检测,分析基因多态性与胃癌发生之间的相关性。结果 IL-1RN rs9005G、A等位基因分布频率在疾病组(68.3%、31.7%)和对照组(77.3%、22.7%)中差异有统计学意义(P<0.05);IL-1RN rs9005GG、GA、AA基因型在疾病组和对照组中分布频率分别为48.0%、40.7%、11.3%和62.0%、30.7%、7.3%,组间差异有统计学意义(P<0.05);与IL-1RN rs9005GG比较,GA和GA+AA携带者患胃癌的风险分别增至1.71倍和1.77倍(P<0.05),在<60岁年龄组中GA+AA基因型携带者患胃癌的风险增至2.23倍,组间差异有统计学意义(P<0.05);未发现IL-17A rs2275913基因多态性与胃癌有关。结论本地区IL-1RN rs9005基因多态性与胃癌发生相关,对胃癌易感人群筛查、防治有一定价值。Objective To assess the relation between polymorphisms of IL-1 and IL-17 and gastric cancer.Methods A case-control design was carried out in this study, which included 150 patients with gastric cancer and 150 controls. The gene polymorphisms of IL-1 RN rs9005 and IL-17 A rs2275913 in patients and controls were analyzed by SNaPshot assay. The correlation between gene polymorphism and the occurrence of gastric cancer was analyzed.Results The distribution frequencies of rs9005 GandAalleles in IL-1 RN were significantly different between the disease group(68. 3% and 31. 7%) and the control group(77. 3% and 22. 7%), with the differences statistically significant(P< 0. 05). The distribution frequencies of IL-1 RN rs9005 GG,GAandAAgenotypes were 48. 0%, 40. 7%, 11. 3% in the disease group and 62. 0%, 30. 7%, 7. 3%in the control group, with the differences of statistical significance(P< 0. 05). Compared with IL-1 RN rs9005 GG, the risk of GAandGA+AAcarriers for gastric cancer increased to 1. 71 times and 1. 77 times(P< 0. 05), and the risk ofGA+AAcarriers for gastric cancer increased to 2. 23 times in < 60 years old age group, with the differences of statistical significance(P<0. 05). No association between IL-17 A rs2275913 gene polymorphism and gastric cancer was found.Conclusion The IL-1 RN rs9005 polymorphism may be correlated with gastric cancer, which has a certain value in the screening of gastric cancer susceptible population.

关 键 词：白细胞介素1 白细胞介素17 基因多态性 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]