Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis  

作　　者：Kevin C Stein 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2021年第11期1985-1985,共1页Sichuan Journal of Physiological Sciences

摘　　要：Ageing is accompanied by a decline in cellular proteostasis,which underlies many age-related protein misfolding diseases1,2.Yet,how ageing impairs proteostasis remains unclear.As nascent polypeptides represent a substantial burden on the proteostasis network3,we hypothesized that altered translational efficiency during ageing could help to drive the collapse of proteostasis.Here we show that ageing alters the kinetics of translation elongation in both Caenorhabditis elegans and Saccharomyces cerevisiae.Ribosome pausing was exacerbated at specific positions in aged yeast and worms.

关 键 词：Ageing TRANSLATIONAL kinetics 

分 类 号：TG1[金属学及工艺—金属学]