代谢组学在肿瘤药物靶点筛选中的应用进展  

Application Progress of Metabolomics in Tumor Drug Target Screening

作　　者：吴玉苹 周勇 蒲娟[2] 李会 章金刚 朱艳平[1] WU Yu-ping;ZHOU Yong;PU Juan;LI Hui;ZHANG Jin-gang;ZHU Yan-ping(College of Life Science and Basic Medicine,Xinxiang University,Xinxiang 453003;College of Veterinary Medicine,China Agricultural University,Beijing 100193;Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,Beijing Center for Disease Prevention and Control,Beijing 100013;Institute of Health Service and Transfusion Medicine,Academy of Military Medical Sciences,Beijing 100850)

机构地区：[1]新乡学院生命科学与基础医学学院,新乡453003 [2]中国农业大学动物医学院,北京100193 [3]北京市疾病预防控制中心食物中毒诊断溯源北京市重点实验室,北京100013 [4]军事医学科学院野战输血研究所,北京100850

出　　处：《生物技术通报》2022年第1期311-318,共8页Biotechnology Bulletin

基　　金：河南省高等学校重点科研项目计划(19B230015);新乡学院博士启动科研资助项目(1366020122);新乡学院横向项目(1344010016);河南省青年骨干教师计划项目(2018GGJS154)。

摘　　要：肿瘤是一种多因素参与造成机体各系统功能平衡紊乱的代谢性疾病,代谢重编程是恶性肿瘤的重要特征之一。研究"代谢指纹图谱"的代谢组学,通过揭示肿瘤或药物引起的宿主内源性代谢物的变化,为肿瘤药物靶点的筛选提供了可能。但目前对代谢组在肿瘤药物靶点筛选中的整体性综述并不多见,因此,本文在介绍了代谢组学筛选肿瘤药物靶点的流程的基础上,然后依次对代谢组学在糖代谢、氨基酸代谢、脂质代谢等能量领域中肿瘤药物靶点筛选及其在揭示肿瘤耐药机制和靶向药物筛选中的应用进行了阐述,最后对代谢组学在肿瘤药物靶点研究中存在的问题以及未来发展趋势进行了探讨,以期为深入研究理解代谢组学在肿瘤机制和药物靶点发现中的重要作用提供参考和科学依据。Tumor is a metabolic disease that is involved in various factors and causes the disorder of the function balance of various systems of the body.Metabolic reprogramming is an important sign of malignant tumor.Metabolomics of studying “metabolic fingerprint” can be used to mine the key metabolites related to tumor and their metabolic reprogramming pathways,and is widely used in the screening of tumor target drugs.However,there are few overall reviews on metabonomics in tumor drug target screening.This paper firstly introduces the process of metabolomics screening tumor drug targets,then elaborates the metabolomics in the screening of tumor drug targets in the fields of glucose metabolism,amino acid metabolism,lipid metabolism and other fields,revealing tumor drug-resistant mechanism,and in the application of screening target drugs.Finally the paper discusses the existing issues and future development trend of metabolomics in the research of tumor drug targets,aiming to provide reference and scientific basis for further studying and understanding the important role of metabolomics in tumor pathogenesis and drug target uncovering.

关 键 词：代谢组学 肿瘤 代谢重编程 药物靶点 

分 类 号：R730[医药卫生—肿瘤]