基于肠道菌群探讨中药防治阿尔茨海默病的研究进展  

Research progress on prevention and treatment of Alzheimer’s disease with traditional Chinese medicine based on gut microbiota

作　　者：王洋 赵健[2] 王迪 杨波[3] 郑时嘉 周忠光 WANG Yang;ZHAO Jian;WANG Di;YANG Bo;ZHENG Shijia;ZHOU Zhongguang(College of Basic Medicine,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;Department of Acupuncture,the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;College of Pharmacy,Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin 150040,China;Tianwenshan Agricultural Development Company,Heilongjiang Province,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第二医院针灸科,黑龙江哈尔滨150040 [3]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [4]天问山农业综合开发股份有限公司,黑龙江哈尔滨150040

出　　处：《中国医药导报》2022年第3期38-42,共5页China Medical Herald

基　　金：黑龙江省应用技术研究与开发计划项目(GA20 C017)。

摘　　要：肠道微生态是近年来生命科学研究的热点。肠道菌群及其代谢产物调节宿主行为与认知功能,与阿尔茨海默病(AD)的发生、发展密切相关,肠道菌群已成为防治AD的新靶点。传统中药在调节肠道菌群方面具有明显优势,广泛应用于AD的防治研究中,通过中药靶向肠道菌群成为抗AD治疗的一个关键突破口。本文阐述了肠道菌群与AD的相关性,综述了中药调控肠道菌群防治AD的研究现状,以期为加强AD的认识和抗AD药物研发提供研究方向和思路。Intestinal microecology is a hotspot of research on life science in recent years.Gut microbiota and its metabolites regulate host’s behavior and cognitive function,and are closely related to the occurrence and development of Alzheimer’s disease(AD),gut microbiota has become a new target for the prevention and treatment of AD.Traditional Chinese medicine has advantages in regulating gut microbiota,and it is widely used in the prevention and treatment of AD.Targeting gut microbiota through traditional Chinese medicine has become a key breakthrough in anti-AD treatment.This paper describes the relationship between gut microbiota and AD,and summarizes the current situation of the research on the control of gut microbiota by traditional Chinese medicine,in order to provide research directions and ideas for strengthening the understanding of AD and the development of anti-AD drugs.

关 键 词：肠道菌群 肠道菌群-肠-脑轴 中药单体 中药复方 阿尔茨海默病 

分 类 号：R749.16[医药卫生—神经病学与精神病学]