雌激素及其受体在克罗恩病发生和发展中作用的研究进展  

Research progress on estrogen and its receptors in occurrence and advance of Crohn's disease

作　　者：武国智 安丽娜 刘敏 王玉平[1,2] 郭庆红 WU Guo-zhi;AN Li-na;LIU Min;WANG Yu-ping;GUO Qing-hong(The First Clinical Medical College, Lanzhou University, Lanzhou 730000;Department of Gastroenterology,Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University,Lanzhou 730000, China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院消化科甘肃省胃肠病重点实验室,甘肃兰州730000

出　　处：《基础医学与临床》2022年第3期494-497,共4页Basic and Clinical Medicine

基　　金：国家重点研发计划(2016YFC0107006);国家自然科学基金(81960430);甘肃省自然科学基金(21JR1RA117);兰州大学第一医院院内基金(ldyyyn2018-38)。

摘　　要：克罗恩病(CD)的发生与内分泌系统的调节紊乱相关,其中雌激素及其受体的失调在CD的发病机制中扮演着重要的作用。研究发现雌激素可以下调相关炎性因子的表达,适当地补充雌激素有助于减轻炎性反应程度。而其受体(GPER、ERα和ERβ)表达也在局部免疫反应方面起作用,三者表达水平的失调介导肠道炎性反应的发生。结合目前的研究来看,雌激素及其受体有望成为研究CD发生发展的新方向。Crohn's disease(CD)is a subtype of inflammatory bowel diseases and may be resulted from endocrine disorders.Estrogen and its receptors exert an important role in the pathogenesis of CD.Studies have revealed that estrogen can down-regulate the expression of inflammatory mediators while estrogen supplementation helps reduce the severity of inflammatory response.The expression of receptors(GPER,ERαand ERβ)also influence local immune responses,and the imbalance of them mediate intestinal inflammation.Nowadays,estrogen and its receptors are expected to become a new rarget in the research of CD.

关 键 词：克罗恩病 炎性肠病 雌激素 受体 机制 

分 类 号：R574[医药卫生—消化系统]