论自身免疫性脑炎责任抗体的致病性  

The pathogenicity of culprit antibody in autoimmune encephalitis

作　　者：陈晟[1] 张仪纵横 沈丁玎 周勤明 CHEN Sheng;ZHANG Yi-zongheng;SHEN Ding-ding;ZHOU Qin-ming(Department of Neurology,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Co-innovation Center of Neuroregeneration,Nantong University,Nantong 226001,Jiangsu,China)

机构地区：[1]上海交通大学医学院附属瑞金医院神经科,200025 [2]南通大学神经再生协同创新中心,226001

出　　处：《中国现代神经疾病杂志》2022年第1期1-7,共7页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：上海申康医院发展中心促进市级医院临床技能与临床创新能力三年行动计划(项目编号:SHDC2020CR2027B);上海人才发展基金资助项目(项目编号:2019044);上海市教育委员会曙光计划项目(项目编号:18SG15);上海市青年拔尖人才项目。

摘　　要：自身免疫性脑炎是一种中枢神经系统自身免疫性疾病,大量新抗体的发现扩增其临床疾病谱,但也为临床表型的精准识别带来一定困难。责任抗体系指同一例患者病程中与一个或多个临床表型有对应因果关系的致病性抗体,这一概念的提出,在自身抗体与临床表型之间建立联系,体现出现代精准医学的理念。明确责任抗体的致病性是理解抗体-临床表型因果关系模式的重中之重。本文总结自身免疫性脑炎责任抗体致病机制研究进展。Autoimmune encephalitis(AE)comprises an important group of autoimmune diseases targeting central nervous system.Although the growing number of new antibodies has amplified our understanding of the disease spectrum of AE,it has also produced challenges to accurately recognize the clinical phenotypes.Culprit antibody refers to the pathogenic antibody causing one or more clinical phenotypes during the disease.This concept establishes a connection between autoantibodies and clinical phenotypes,and also reflects the idea of modern precision medicine.The most important for better understanding the antibody-phenotype causality is to ascertain the pathogenicity of culprit antibody.Accordingly,we will discuss the recent progress in pathogenesis of the culprit antibody in AE.

关 键 词：脑炎 自身免疫疾病 抗体 毒力 综述 

分 类 号：R742.9[医药卫生—神经病学与精神病学]