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作 者:段云[1] 杨雯 杨颖卓[1] 何文果[1] 王乔 徐蓉生[1] DUAN Yun;YANG Wen;YANG Ying-zhuo;HE Wen-guo;WANG Qiao;XU Rong-sheng(Department of Nuclear Medicine,Sichuan Cancer Hospital,Chengdu,Sichuan 610041,China)
机构地区:[1]四川省肿瘤医院核医学科,四川成都610041
出 处:《颈腰痛杂志》2022年第1期21-25,32,共6页The Journal of Cervicodynia and Lumbodynia
摘 要:目的使用SPECT SUV进行定量评估,客观比较脊柱颈胸段骨关节炎和骨转移之间的^(99m)Tc-MDP示踪剂摄取,探讨SUV定量在骨关节炎和骨转移中的诊断价值。方法回顾性分析在本院诊断为肿瘤的患者57例,用^(99m)Tc-MDP对其进行SPECT/CT骨显像。骨显像共发现187个高代谢颈胸椎病变,其中骨转移组143个,骨关节炎组44个,同时将每个患者正常腰椎的SUVmax测量值作为对照组(57个)。对187个病变的SUVmax进行了定量分析。结果对照组的SUVmax水平为9.1±2.0,骨关节炎组为13.9±5.6,骨转移为22.1±8.8,骨转移组SUVmax水平明显高于骨关节炎组、对照组,骨关节炎组SUVmax水平明显高于对照组,差异均有统计学意义(P<0.01)。ROC曲线分析发现,骨转移组-对照组的曲线下面积(AUC=0.922)最高,骨关节炎组-对照组AUC值为0.884,骨转移组-骨关节炎组AUC值为0.826。进一步比较骨转移组中的非成骨性骨转移灶SUVmax水平对骨关节炎组的诊断效能,ROC曲线显示AUC为0.769,非成骨性骨转移的SUVmax水平明显高于骨关节炎组,差异有统计学意义(P<0.01)。结论SPECT/CT骨转移灶的SUV max值明显高于骨关节炎,SUV max的定量评估可补充对骨转移灶和骨关节炎的定性分析。Objective To evaluate quantitatively with SPECT SUV,objectively compare the uptake of 99m TC-MDP between spinal cervicothoracic osteoarthritis and bone metastasis,and to explore the diagnostic value of SUV quantification in osteoarthritis and bone metastasis.Methods Fifty-seven patients diagnosed with tumors at our hospital were retrospectively analyzed and treated with 99m TC-MDP for SPECT/CT bone imaging.A total of 187 hypermetabolic cervical and thoracic lesions were detected by bone imaging,including 143 in the bone metastasis group and 44 in the osteoarthritis group.Meanwhile,SUVmax values of normal lumbar vertebrae were taken for each patient as the control group(57).The quantitative analysis of SUVmax in 187 lesions was carried out.Results The SUVmax levels of the control group,osteoarthritis group and bone metastasis group were(9.1±2.0),(13.9±5.6)and(22.1±8.8).The SUVmax level of the bone metastasis group was significantly higher than that of the osteoarthritis group and the control group,and the SUVmax level of the osteoarthritis group was significantly higher than that of the control group,with statistically significant differences(P<0.01).According to ROC curve analysis,the area under the curve(AUC)of the bone metastasis group-control group(AUC=0.922)was the highest,the AUC value of the osteoarthritis group-control group and the bone metastasis group-osteoarthritis group was 0.884 and 0.826,respectively.The ROC curve showed an AUC of 0.769.The SUVmax level of non-osseous bone metastasis in the bone metastasis group was significantly higher than that in the osteoarthritis group,and the difference was statistically significant(P<0.01).Conclusion The value of SPECT/CT SUVmax with bone metastasis was significantly higher than that of osteoarthritis,and the quantitative evaluation of SUVmax can supplement the qualitative analysis of bone metastasis and osteoarthritis.
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