Peg-IFN在HBV相关HCC手术切除术后和(或)介入术后抗复发中的临床应用  

Clinical application of Peg-IFN in anti-relapse after resection and/or intervention for HBV-related HCC

作　　者：杜景华 张影 DU Jinghua;ZHANG Ying(Department of Liver DiseasesⅥ,Dalian Public Health Clinical Center,Dalian Sixth People′s Hospital,Dalian 116033,China)

机构地区：[1]大连市公共卫生临床中心大连市第六人民医院肝病六科,辽宁大连116033

出　　处：《中国现代医生》2022年第3期1-3,20,共4页China Modern Doctor

基　　金：辽宁省自然科学基金计划项目(20180551027)。

摘　　要：目的评价聚乙二醇干扰素Peg-IFN在乙型肝炎病毒(HBV)相关原发性肝癌(HCC)手术切除术后及介入术后抗复发中的应用价值。方法随机选取2011年1月至2015年6月大连市第六人民医院接受手术切除和(或)介入术后的HBV相关HCC患者60例,患者无性别限制,年龄均>18周岁;其中接受术后Peg-IFN治疗的患者30例;术后未接受Peg-IFN治疗患者30例。统计两组患者术后1年、2年、3年及5年的复发率、生存率。结果接受Peg-IFN治疗组1年、2年、3年及5年的生存率为93.33%(28/30)、83.33%(25/30)、60.00%(18/30)、50.00%(15/30);未接受Peg-IFN治疗组1年、2年、3年及5年的生存率为76.67%(23/30)、63.33%(19/30)、53.33%(16/30)、46.67%(14/30)。接受Peg-IFN治疗组1年、2年、3年及5年的复发率分别为6.67%(2/30)、23.30%(7/30)、46.67%(14/30)、70.00%(21/30);未接受Peg-IFN治疗组1年、2年、3年及5年的复发率分别为26.67%(8/30)、46.67%(14/30)、66.67%(20/30)、86.67%(26/30)。结论HBV相关HCC患者手术切除术后和(或)介入术后应用Peg-IFN可更好地降低术后复发率,提高患者生存率。Objective To evaluate the application value of polyethylene glycol interferon(Peg-IFN)in anti-relapse after resection and/or intervention for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC).Methods A total of 60 patients with HBV-related HCC older than 18 years old(male or female)who received resection and/or intervention from January 2011 to June 2015 in Dalian Sixth People′s Hospital were randomly selected as the study subjects.30 patients received postoperative Peg-IFN treatment,and another 30 patients did not receive postoperative Peg-IFN treatment.The relapse rates and survival rates of patients in both groups at 1,2,3 and 5 years after operation were counted.Results The survival rates at 1,2,3 and 5 years after operation in the group receiving Peg-IFN treatment were 93.33%(28/30),83.33%(25/30),60.00%(18/30)and 50.00%(15/30)respectively,while those in the group not receiving Peg-IFN treatment were 76.67%(23/30),63.33%(19/30),53.33%(16/30)and 46.67%(14/30)respectively.The relapse rates at 1,2,3 and 5 years after operation in the group receiving Peg-IFN treatment were 6.67%(2/30),23.30%(7/30),46.67%(14/30)and 70.00%(21/30)respectively,while those in the group not receiving Peg-IFN treatment were 26.67%(8/30),46.67%(14/30),66.67%(20/30)and 86.67%(26/30)respectively.Conclusion The application of Peg-IFN in patients with HBV-related HCC after resection and/or intervention can better reduce the postoperative relapse rate and improve the survival rate of patients.

关 键 词：PEG-IFN HBV HCC 手术切除 介入术后 抗复发 

分 类 号：R735.7[医药卫生—肿瘤]